The clinical potential of microRNAs

The clinical potential of microRNAs

<p>Abstract</p> <p>MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, re...

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Main Authors: Wang Xin W, Ji Junfang, Budhu Anuradha
Format: Article
Language:English
Published: BMC 2010-10-01
Series:Journal of Hematology & Oncology
Online Access:http://www.jhoonline.org/content/3/1/37
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spelling doaj-4952060330a444c5a7bce52b241e1ca42020-11-25T00:45:01ZengBMCJournal of Hematology & Oncology1756-87222010-10-01313710.1186/1756-8722-3-37The clinical potential of microRNAsWang Xin WJi JunfangBudhu Anuradha<p>Abstract</p> <p>MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression. In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed.</p> http://www.jhoonline.org/content/3/1/37
collection DOAJ
language English
format Article
sources DOAJ
author Wang Xin W
Ji Junfang
Budhu Anuradha
spellingShingle Wang Xin W
Ji Junfang
Budhu Anuradha
The clinical potential of microRNAs
Journal of Hematology & Oncology
author_facet Wang Xin W
Ji Junfang
Budhu Anuradha
author_sort Wang Xin W
title The clinical potential of microRNAs
title_short The clinical potential of microRNAs
title_full The clinical potential of microRNAs
title_fullStr The clinical potential of microRNAs
title_full_unstemmed The clinical potential of microRNAs
title_sort clinical potential of micrornas
publisher BMC
series Journal of Hematology & Oncology
issn 1756-8722
publishDate 2010-10-01
description <p>Abstract</p> <p>MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression. In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed.</p>
url http://www.jhoonline.org/content/3/1/37
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