Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors
Animals prenatally exposed to valproic acid (VPA), an antiepileptic agent, have been used as a model for autism spectrum disorders (ASDs). Previous studies have identified enhanced NMDA receptor (NMDAR) function in the brain of VPA rats, and demonstrated that pharmacological suppression of NMDAR fun...
Main Authors: | Jaeseung eKang, Eunjoon eKim |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-05-01
|
Series: | Frontiers in Molecular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00017/full |
Similar Items
-
Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice
by: Ye-Eun Yoo, et al.
Published: (2021-09-01) -
Late onset deficits in synaptic plasticity in the valproic acid rat model of autism
by: Henry Giles Stratten Martin, et al.
Published: (2014-01-01) -
Pentylenetetrazole-induced seizures in developing rats prenatally exposed to valproic acid
by: Angel A. Puig-Lagunes, et al.
Published: (2016-11-01) -
Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero
by: Hiroko Kotajima-Murakami, et al.
Published: (2019-01-01) -
Behavioral and neuroanatomical effects of prenatal exposure to valproic acid in the mouse : relevance to autism spectrum disorders
by: Wei, Ran, et al.
Published: (2014)