Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

Objective: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. Methods: In present study, 147...

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Main Authors: Zonglin Shen, Yuqi Cheng, Shuran Yang, Nan Dai, Jing Ye, Xiaoyan Liu, Jin Lu, Na Li, Fang Liu, Yi Lu, Xuejin Sun, Xiufeng Xu
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:NeuroImage: Clinical
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158216301528
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spelling doaj-49634db9e73c4e0c897d7ffed79cc8132020-11-24T22:31:50ZengElsevierNeuroImage: Clinical2213-15822016-01-0112C49249810.1016/j.nicl.2016.08.016Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onsetZonglin Shen0Yuqi Cheng1Shuran Yang2Nan Dai3Jing Ye4Xiaoyan Liu5Jin Lu6Na Li7Fang Liu8Yi Lu9Xuejin Sun10Xiufeng Xu11Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, ChinaObjective: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. Methods: In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18–29) and the later adult onset group (age 30–44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images. Results: Widespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group. Conclusions: The GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.http://www.sciencedirect.com/science/article/pii/S2213158216301528Major depressive disorderDifferent age at onsetMagnetic resonance imagingGrey matter volume
collection DOAJ
language English
format Article
sources DOAJ
author Zonglin Shen
Yuqi Cheng
Shuran Yang
Nan Dai
Jing Ye
Xiaoyan Liu
Jin Lu
Na Li
Fang Liu
Yi Lu
Xuejin Sun
Xiufeng Xu
spellingShingle Zonglin Shen
Yuqi Cheng
Shuran Yang
Nan Dai
Jing Ye
Xiaoyan Liu
Jin Lu
Na Li
Fang Liu
Yi Lu
Xuejin Sun
Xiufeng Xu
Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
NeuroImage: Clinical
Major depressive disorder
Different age at onset
Magnetic resonance imaging
Grey matter volume
author_facet Zonglin Shen
Yuqi Cheng
Shuran Yang
Nan Dai
Jing Ye
Xiaoyan Liu
Jin Lu
Na Li
Fang Liu
Yi Lu
Xuejin Sun
Xiufeng Xu
author_sort Zonglin Shen
title Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
title_short Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
title_full Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
title_fullStr Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
title_full_unstemmed Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
title_sort changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2016-01-01
description Objective: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. Methods: In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18–29) and the later adult onset group (age 30–44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images. Results: Widespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group. Conclusions: The GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.
topic Major depressive disorder
Different age at onset
Magnetic resonance imaging
Grey matter volume
url http://www.sciencedirect.com/science/article/pii/S2213158216301528
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