Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma

Objective: To study the effect of integrated surgery + radiotherapy + chemotherapy treatment on the survival status and serum indexes in patients with gallbladder carcinoma. Methods: A total of 68 patients with gallbladder carcinoma were divided into observation group (received integrated surgery...

Full description

Bibliographic Details
Main Authors: Zhi-Li Wei, Xiao-Di Zhang, Ping-Hui Song, Zhi-Xiang Wang
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2016-12-01
Series:Journal of Hainan Medical University
Subjects:
Online Access:http://www.hnykdxxb.com/PDF/201624/35.pdf
id doaj-49682aeaa4ed405188c1f6dcc241ceb9
record_format Article
spelling doaj-49682aeaa4ed405188c1f6dcc241ceb92020-11-25T00:46:05ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-12-012224136139Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinomaZhi-Li Wei0Xiao-Di Zhang1Ping-Hui Song2Zhi-Xiang Wang3Department of Hepatobiliary Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang City, Shaanxi Province, 712000, ChinaDepartment of Hepatobiliary Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang City, Shaanxi Province, 712000, ChinaDepartment of Hepatobiliary Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang City, Shaanxi Province, 712000, ChinaDepartment of Hepatobiliary Surgery, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang City, Shaanxi Province, 712000, ChinaObjective: To study the effect of integrated surgery + radiotherapy + chemotherapy treatment on the survival status and serum indexes in patients with gallbladder carcinoma. Methods: A total of 68 patients with gallbladder carcinoma were divided into observation group (received integrated surgery + radiotherapy + chemotherapy treatment) and control group (received surgery + radiotherapy) according to different treatments. Differences in the content of tumor markers, growth factors and adhesion molecules in serum as well as the median survival time and survival rate in 5 years of follow-up were compared between the two groups 1 month after treatment. Results: Tumor markers β2-MG, CA19-9, CA242, CA125, CA724, CEA and AFP content in serum of observation group after treatment were significantly lower than those of control group; growth factors VEGF, FGF, EGFR and HER2 content in serum were significantly lower than those of control group while IGFBP-2 and IGFBP-3 content were significantly higher than those of control group; adhesion molecules E-selectin, ICAM-1, VCAM-1 and sE-Cd content in serum were significantly lower than those of control group; the median survival time of 5-year follow-up as well as 1-, 3- and 5-year survival rate were significantly greater than those of control group. Conclusions: Integrated treatment of surgery + radiotherapy + chemotherapy can optimize the short-term and long-term curative effect in patients with gallbladder carcinoma.http://www.hnykdxxb.com/PDF/201624/35.pdfGallbladder carcinomaIntegrated treatmentSurvival analysisSerum indexes
collection DOAJ
language English
format Article
sources DOAJ
author Zhi-Li Wei
Xiao-Di Zhang
Ping-Hui Song
Zhi-Xiang Wang
spellingShingle Zhi-Li Wei
Xiao-Di Zhang
Ping-Hui Song
Zhi-Xiang Wang
Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
Journal of Hainan Medical University
Gallbladder carcinoma
Integrated treatment
Survival analysis
Serum indexes
author_facet Zhi-Li Wei
Xiao-Di Zhang
Ping-Hui Song
Zhi-Xiang Wang
author_sort Zhi-Li Wei
title Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
title_short Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
title_full Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
title_fullStr Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
title_full_unstemmed Effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
title_sort effect of integrated surgery + radiotherapy + chemotherapy treatment on survival status and serum indexes in patients with gallbladder carcinoma
publisher Editorial Board of Journal of Hainan Medical University
series Journal of Hainan Medical University
issn 1007-1237
1007-1237
publishDate 2016-12-01
description Objective: To study the effect of integrated surgery + radiotherapy + chemotherapy treatment on the survival status and serum indexes in patients with gallbladder carcinoma. Methods: A total of 68 patients with gallbladder carcinoma were divided into observation group (received integrated surgery + radiotherapy + chemotherapy treatment) and control group (received surgery + radiotherapy) according to different treatments. Differences in the content of tumor markers, growth factors and adhesion molecules in serum as well as the median survival time and survival rate in 5 years of follow-up were compared between the two groups 1 month after treatment. Results: Tumor markers β2-MG, CA19-9, CA242, CA125, CA724, CEA and AFP content in serum of observation group after treatment were significantly lower than those of control group; growth factors VEGF, FGF, EGFR and HER2 content in serum were significantly lower than those of control group while IGFBP-2 and IGFBP-3 content were significantly higher than those of control group; adhesion molecules E-selectin, ICAM-1, VCAM-1 and sE-Cd content in serum were significantly lower than those of control group; the median survival time of 5-year follow-up as well as 1-, 3- and 5-year survival rate were significantly greater than those of control group. Conclusions: Integrated treatment of surgery + radiotherapy + chemotherapy can optimize the short-term and long-term curative effect in patients with gallbladder carcinoma.
topic Gallbladder carcinoma
Integrated treatment
Survival analysis
Serum indexes
url http://www.hnykdxxb.com/PDF/201624/35.pdf
work_keys_str_mv AT zhiliwei effectofintegratedsurgeryradiotherapychemotherapytreatmentonsurvivalstatusandserumindexesinpatientswithgallbladdercarcinoma
AT xiaodizhang effectofintegratedsurgeryradiotherapychemotherapytreatmentonsurvivalstatusandserumindexesinpatientswithgallbladdercarcinoma
AT pinghuisong effectofintegratedsurgeryradiotherapychemotherapytreatmentonsurvivalstatusandserumindexesinpatientswithgallbladdercarcinoma
AT zhixiangwang effectofintegratedsurgeryradiotherapychemotherapytreatmentonsurvivalstatusandserumindexesinpatientswithgallbladdercarcinoma
_version_ 1725267051581276160