Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.

Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial ca...

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Bibliographic Details
Main Authors: J R Falck, V J Schueler, H R Jacobson, A K Siddhanta, B Pramanik, J Capdevila
Format: Article
Language:English
Published: Elsevier 1987-07-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752038651X
Description
Summary:Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid chromatography-mass spectral analysis of the corresponding hydrogenated pentafluorobenzyl esters revealed the presence of the 8,9- and 14,15-epoxyeicosatrienoate regioisomers. These results, in conjunction with the documented in vitro biological activities of the arachidonate epoxygenase metabolites, suggest a role for them in renal function.
ISSN:0022-2275

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