Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers
Abstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vi...
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doaj-497b9624a44d4061a993bfb8d568c2c72020-12-08T00:19:15ZengNature Publishing GroupScientific Reports2045-23222017-06-017111110.1038/s41598-017-03851-1Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibersYiwa Pan0Xin Zhou1Yongzhen Wei2Qiuying Zhang3Ting Wang4Meifeng Zhu5Wen Li6Rui Huang7Ruming Liu8Jingrui Chen9Guanwei Fan10Kai Wang11Deling Kong12Qiang Zhao13State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityUrban Transport Emission Control Research Centre, College of Environmental Science and Engineering, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityCenter for Research and Development of Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese MedicineCenter for Research and Development of Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai UniversityAbstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-diameter hybrid vascular graft was prepared by co-electrospinning PCL and PDS fibers. The incorporation of PDS improves mechanical properties, hydrophilicity of the hybrid grafts compared to PCL grafts. The in vitro/vivo degradation assay showed that PDS fibers completely degraded within 12 weeks, which resulted in the increased pore size of PCL/PDS grafts. The healing characteristics of the hybrid grafts were evaluated by implantation in rat abdominal aorta replacement model for 1 and 3 months. Color Doppler ultrasound demonstrated PCL/PDS grafts had good patency, and did not show aneurysmal dilatation. Immunofluorescence staining showed the coverage of endothelial cells (ECs) was significantly enhanced in PCL/PDS grafts due to the improved surface hydrophilicity. The degradation of PDS fibers provided extra space, which facilitated vascular smooth muscle regeneration within PCL/PDS grafts. These results suggest that the hybrid PCL/PDS graft may be a promising candidate for the small-diameter vascular grafts.https://doi.org/10.1038/s41598-017-03851-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao |
spellingShingle |
Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers Scientific Reports |
author_facet |
Yiwa Pan Xin Zhou Yongzhen Wei Qiuying Zhang Ting Wang Meifeng Zhu Wen Li Rui Huang Ruming Liu Jingrui Chen Guanwei Fan Kai Wang Deling Kong Qiang Zhao |
author_sort |
Yiwa Pan |
title |
Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
title_short |
Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
title_full |
Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
title_fullStr |
Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
title_full_unstemmed |
Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
title_sort |
small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-06-01 |
description |
Abstract Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-diameter hybrid vascular graft was prepared by co-electrospinning PCL and PDS fibers. The incorporation of PDS improves mechanical properties, hydrophilicity of the hybrid grafts compared to PCL grafts. The in vitro/vivo degradation assay showed that PDS fibers completely degraded within 12 weeks, which resulted in the increased pore size of PCL/PDS grafts. The healing characteristics of the hybrid grafts were evaluated by implantation in rat abdominal aorta replacement model for 1 and 3 months. Color Doppler ultrasound demonstrated PCL/PDS grafts had good patency, and did not show aneurysmal dilatation. Immunofluorescence staining showed the coverage of endothelial cells (ECs) was significantly enhanced in PCL/PDS grafts due to the improved surface hydrophilicity. The degradation of PDS fibers provided extra space, which facilitated vascular smooth muscle regeneration within PCL/PDS grafts. These results suggest that the hybrid PCL/PDS graft may be a promising candidate for the small-diameter vascular grafts. |
url |
https://doi.org/10.1038/s41598-017-03851-1 |
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