TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering a...

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Main Authors:	Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02309-5

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spelling	doaj-497b996aa1574d6a946f5ee6787fec3f2021-06-27T11:27:14ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111510.1038/s42003-021-02309-5TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activityXiaojie Yu0Sonya James1James H. Felce2Blanka Kellermayer3David A. Johnston4H. T. Claude Chan5Christine A. Penfold6Jinny Kim7Tatyana Inzhelevskaya8C. Ian Mockridge9Yasunori Watanabe10Max Crispin11Ruth R. French12Patrick J. Duriez13Leon R. Douglas14Martin J. Glennie15Mark S. Cragg16Antibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineONI UK, Linacre House, Banbury RoadONI UK, Linacre House, Banbury RoadBiomedical Imaging Unit, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineSchool of Biological Sciences, University of SouthamptonSchool of Biological Sciences, University of SouthamptonAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineCRUK Protein Core Facility, University of Southampton Faculty of MedicineCRUK Protein Core Facility, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineAntibody and Vaccine Group, School of Cancer Sciences, University of Southampton Faculty of MedicineYu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.https://doi.org/10.1038/s42003-021-02309-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg
spellingShingle	Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity Communications Biology
author_facet	Xiaojie Yu Sonya James James H. Felce Blanka Kellermayer David A. Johnston H. T. Claude Chan Christine A. Penfold Jinny Kim Tatyana Inzhelevskaya C. Ian Mockridge Yasunori Watanabe Max Crispin Ruth R. French Patrick J. Duriez Leon R. Douglas Martin J. Glennie Mark S. Cragg
author_sort	Xiaojie Yu
title	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_short	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_full	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_fullStr	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_full_unstemmed	TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
title_sort	tnf receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-06-01
description	Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.
url	https://doi.org/10.1038/s42003-021-02309-5
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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity

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