Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas
Abstract Background Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far. Methods Literature-based data mining was conducted to identify genes, molecule, and cell processes link...
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doaj-497f65aab75a4b4bb6efd730fe3484b72021-04-02T17:34:22ZengBMCBMC Medical Genetics1471-23502020-10-0121S11710.1186/s12881-020-01099-7Understanding the molecular association between hyperkalemia and lung squamous cell carcinomasXianping Meng0Hongyan Lu1Xia Jiang2Bin Huang3Song Wu4Guiping Yu5Hongbao Cao6Department of Radiology, Jiangyin People’s HospitalDepartment of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical CollegeDepartment of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical CollegeDepartment of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical CollegeDepartment of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical CollegeDepartment of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical CollegeDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical UniversityAbstract Background Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far. Methods Literature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and LSCC. Pathway analysis was performed to explore the interactive network, common-target network, and common-regulator network for both disorders. Then, a mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 278 healthy controls) was performed to test the hypothesis that genes influencing hyperkalemia may also play roles in LSCC. Results There was a significant overlap between the genes implicated with both diseases (20 genes, p-value = 4.98e-15), which counts for 16% of all hyperkalemia genes (125 genes). Network analysis identified 12 molecules as common targets for hyperkalemia and LSCC, and 19 molecules as common regulators. Moreover, 19 molecules were identified within an interactive network, through which hyperkalemia and LSCC could exert influence on each other. In addition, meta-analysis identified one hyperkalemia promoter, SPP1, as a novel contributor for LSCC (LFC = 2.64; p-value = 2.81e-6). MLR analysis suggests geographical region as an influential factor for the expression levels of SPP1 in LSCC patients (p value = 0.036, 0.054). Conclusion Our results showed that there was a common molecular basis for the pathology of both hyperkalemia and LSCC, and that genes promoting hyperkalemia might also play roles in the development of LSCC. However, this study did not suggest hypercalcemia as a casual factor for LSCC.http://link.springer.com/article/10.1186/s12881-020-01099-7HyperkalemiaLung squamous cell carcinomasMega-analysisPathway analysisMultiple linear regression analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xianping Meng Hongyan Lu Xia Jiang Bin Huang Song Wu Guiping Yu Hongbao Cao |
spellingShingle |
Xianping Meng Hongyan Lu Xia Jiang Bin Huang Song Wu Guiping Yu Hongbao Cao Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas BMC Medical Genetics Hyperkalemia Lung squamous cell carcinomas Mega-analysis Pathway analysis Multiple linear regression analysis |
author_facet |
Xianping Meng Hongyan Lu Xia Jiang Bin Huang Song Wu Guiping Yu Hongbao Cao |
author_sort |
Xianping Meng |
title |
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
title_short |
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
title_full |
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
title_fullStr |
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
title_full_unstemmed |
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
title_sort |
understanding the molecular association between hyperkalemia and lung squamous cell carcinomas |
publisher |
BMC |
series |
BMC Medical Genetics |
issn |
1471-2350 |
publishDate |
2020-10-01 |
description |
Abstract Background Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far. Methods Literature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and LSCC. Pathway analysis was performed to explore the interactive network, common-target network, and common-regulator network for both disorders. Then, a mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 278 healthy controls) was performed to test the hypothesis that genes influencing hyperkalemia may also play roles in LSCC. Results There was a significant overlap between the genes implicated with both diseases (20 genes, p-value = 4.98e-15), which counts for 16% of all hyperkalemia genes (125 genes). Network analysis identified 12 molecules as common targets for hyperkalemia and LSCC, and 19 molecules as common regulators. Moreover, 19 molecules were identified within an interactive network, through which hyperkalemia and LSCC could exert influence on each other. In addition, meta-analysis identified one hyperkalemia promoter, SPP1, as a novel contributor for LSCC (LFC = 2.64; p-value = 2.81e-6). MLR analysis suggests geographical region as an influential factor for the expression levels of SPP1 in LSCC patients (p value = 0.036, 0.054). Conclusion Our results showed that there was a common molecular basis for the pathology of both hyperkalemia and LSCC, and that genes promoting hyperkalemia might also play roles in the development of LSCC. However, this study did not suggest hypercalcemia as a casual factor for LSCC. |
topic |
Hyperkalemia Lung squamous cell carcinomas Mega-analysis Pathway analysis Multiple linear regression analysis |
url |
http://link.springer.com/article/10.1186/s12881-020-01099-7 |
work_keys_str_mv |
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