Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses
Rabies virus (RABV) and other lyssaviruses can cause rabies and rabies-like diseases, which are a persistent public health threat to humans and other mammals. Lyssaviruses exhibit distinct characteristics in terms of geographical distribution and host specificity, indicative of a long-standing diver...
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doaj-4982e915db174ac99283b5ded67487ab2020-11-25T00:42:24ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01198239710.3390/ijms19082397ijms19082397Comprehensive Analysis of Codon Usage on Rabies Virus and Other LyssavirusesXu Zhang0Yuchen Cai1Xiaofeng Zhai2Jie Liu3Wen Zhao4Senlin Ji5Shuo Su6Jiyong Zhou7MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaMOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, ChinaKey Laboratory of Animal Virology of Ministry of Agriculture, Department of Veterinary Medicine, Zhejiang University, Hangzhou 310058, ChinaRabies virus (RABV) and other lyssaviruses can cause rabies and rabies-like diseases, which are a persistent public health threat to humans and other mammals. Lyssaviruses exhibit distinct characteristics in terms of geographical distribution and host specificity, indicative of a long-standing diversification to adapt to the environment. However, the evolutionary diversity of lyssaviruses, in terms of codon usage, is still unclear. We found that RABV has the lowest codon usage bias among lyssaviruses strains, evidenced by its high mean effective number of codons (ENC) (53.84 ± 0.35). Moreover, natural selection is the driving force in shaping the codon usage pattern of these strains. In summary, our study sheds light on the codon usage patterns of lyssaviruses, which can aid in the development of control strategies and experimental research.http://www.mdpi.com/1422-0067/19/8/2397RABVlyssavirusescodon usage biasnatural selection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu Zhang Yuchen Cai Xiaofeng Zhai Jie Liu Wen Zhao Senlin Ji Shuo Su Jiyong Zhou |
spellingShingle |
Xu Zhang Yuchen Cai Xiaofeng Zhai Jie Liu Wen Zhao Senlin Ji Shuo Su Jiyong Zhou Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses International Journal of Molecular Sciences RABV lyssaviruses codon usage bias natural selection |
author_facet |
Xu Zhang Yuchen Cai Xiaofeng Zhai Jie Liu Wen Zhao Senlin Ji Shuo Su Jiyong Zhou |
author_sort |
Xu Zhang |
title |
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses |
title_short |
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses |
title_full |
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses |
title_fullStr |
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses |
title_full_unstemmed |
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses |
title_sort |
comprehensive analysis of codon usage on rabies virus and other lyssaviruses |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-08-01 |
description |
Rabies virus (RABV) and other lyssaviruses can cause rabies and rabies-like diseases, which are a persistent public health threat to humans and other mammals. Lyssaviruses exhibit distinct characteristics in terms of geographical distribution and host specificity, indicative of a long-standing diversification to adapt to the environment. However, the evolutionary diversity of lyssaviruses, in terms of codon usage, is still unclear. We found that RABV has the lowest codon usage bias among lyssaviruses strains, evidenced by its high mean effective number of codons (ENC) (53.84 ± 0.35). Moreover, natural selection is the driving force in shaping the codon usage pattern of these strains. In summary, our study sheds light on the codon usage patterns of lyssaviruses, which can aid in the development of control strategies and experimental research. |
topic |
RABV lyssaviruses codon usage bias natural selection |
url |
http://www.mdpi.com/1422-0067/19/8/2397 |
work_keys_str_mv |
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