Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study
Abstract Background Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D...
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doaj-4984292c3c1247c8b7211930f78114652020-11-25T03:35:02ZengBMCBMC Endocrine Disorders1472-68232020-06-012011710.1186/s12902-020-00560-1Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional studyYingchao Chen0Jing Cheng1Yi Chen2Ningjian Wang3Fangzhen Xia4Chi Chen5Bing Han6Yingli Lu7Institute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineInstitute and department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineAbstract Background Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population. Methods We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9220 subjects were analyzed. Serum 25(OH) D, SUA, fasting plasma glucose (FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status. Results We enrolled 9220 Chinese adults, including 3681 males (age 55.57 ± 13.23 years) and 5539 females (age 54.31 ± 12.83 years). The levels of SUA were 352.07 ± 79.25 nmol/L and 269.29 ± 64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH) D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001). Conclusions SUA was positively associated with 25(OH) D in the eastern Chinese population. Higher levels of serum 25(OH) D may be a potential predictor of HUA.http://link.springer.com/article/10.1186/s12902-020-00560-1Uric acidVitamin DHyperuricemiaPublic health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yingchao Chen Jing Cheng Yi Chen Ningjian Wang Fangzhen Xia Chi Chen Bing Han Yingli Lu |
spellingShingle |
Yingchao Chen Jing Cheng Yi Chen Ningjian Wang Fangzhen Xia Chi Chen Bing Han Yingli Lu Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study BMC Endocrine Disorders Uric acid Vitamin D Hyperuricemia Public health |
author_facet |
Yingchao Chen Jing Cheng Yi Chen Ningjian Wang Fangzhen Xia Chi Chen Bing Han Yingli Lu |
author_sort |
Yingchao Chen |
title |
Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study |
title_short |
Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study |
title_full |
Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study |
title_fullStr |
Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study |
title_full_unstemmed |
Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study |
title_sort |
association between serum vitamin d and uric acid in the eastern chinese population: a population-based cross-sectional study |
publisher |
BMC |
series |
BMC Endocrine Disorders |
issn |
1472-6823 |
publishDate |
2020-06-01 |
description |
Abstract Background Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population. Methods We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9220 subjects were analyzed. Serum 25(OH) D, SUA, fasting plasma glucose (FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status. Results We enrolled 9220 Chinese adults, including 3681 males (age 55.57 ± 13.23 years) and 5539 females (age 54.31 ± 12.83 years). The levels of SUA were 352.07 ± 79.25 nmol/L and 269.29 ± 64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH) D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001). Conclusions SUA was positively associated with 25(OH) D in the eastern Chinese population. Higher levels of serum 25(OH) D may be a potential predictor of HUA. |
topic |
Uric acid Vitamin D Hyperuricemia Public health |
url |
http://link.springer.com/article/10.1186/s12902-020-00560-1 |
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