The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women
Introduction. Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. Material and Methods. A sample size of 250 was ana...
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doaj-498d2ad763ee4f9dacac48ad908b99c82020-11-25T03:18:56ZengHindawi LimitedInfectious Diseases in Obstetrics and Gynecology1064-74491098-09972020-01-01202010.1155/2020/34176323417632The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African WomenWendy N. Phoswa0Thajasvarie Naicker1Veron Ramsuran2Jagidesa Moodley3Discipline of Obstetrics and Gynecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South AfricaOptics and Imaging Centre, University of KwaZulu-Natal, Durban, South AfricaKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South AfricaWomen’s Health and HIV Research Group, University of KwaZulu-Natal, Durban, South AfricaIntroduction. Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. Material and Methods. A sample size of 250 was analysed: normotensives (n=150; N) and preeclamptics (n=100; PE). Normotensives were further stratified into HIV negative (n=90), HAART-acute (n=30), and HAART-chronic (n=30). The PE group was divided into early onset (n=50; EOPE) and late onset (n=50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative (n=30), HAART-acute (n=10), and HAART-chronic (n=10). Analysis of IL-17A was performed using a multiple Bio-Plex immunoassay method. Results. Pregnancy type: the levels of IL-17A were increased in PE compared to N (P=0.0014). Gestational age: the levels of IL-17A were increased in EOPE compared to N group (P=0.0113). A significant increase in the levels of IL-17A in LOPE compared to N was observed (P=0.0063). HIV status: the levels of IL-17A were increased in PE compared to N (P=0.0114) and in EOPE compared to N groups (P=0.0071). HAART duration: the concentration of IL-17A was increased in HAART-chronic PE compared to N groups (P=0.0062). There was also an increase in the levels of IL-17A in EOPE compared to N (P=0.0029). Conclusion. The study demonstrates that IL-17A is involved in the pathophysiology of PE and that in the presence of HIV infection, chronic HAART administration predisposes women to the development of EOPE.http://dx.doi.org/10.1155/2020/3417632 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wendy N. Phoswa Thajasvarie Naicker Veron Ramsuran Jagidesa Moodley |
spellingShingle |
Wendy N. Phoswa Thajasvarie Naicker Veron Ramsuran Jagidesa Moodley The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women Infectious Diseases in Obstetrics and Gynecology |
author_facet |
Wendy N. Phoswa Thajasvarie Naicker Veron Ramsuran Jagidesa Moodley |
author_sort |
Wendy N. Phoswa |
title |
The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women |
title_short |
The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women |
title_full |
The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women |
title_fullStr |
The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women |
title_full_unstemmed |
The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women |
title_sort |
role of highly active antiretroviral therapy (haart) on interleukin 17a (il-17a) in normotensive and preeclamptic black south african women |
publisher |
Hindawi Limited |
series |
Infectious Diseases in Obstetrics and Gynecology |
issn |
1064-7449 1098-0997 |
publishDate |
2020-01-01 |
description |
Introduction. Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. Material and Methods. A sample size of 250 was analysed: normotensives (n=150; N) and preeclamptics (n=100; PE). Normotensives were further stratified into HIV negative (n=90), HAART-acute (n=30), and HAART-chronic (n=30). The PE group was divided into early onset (n=50; EOPE) and late onset (n=50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative (n=30), HAART-acute (n=10), and HAART-chronic (n=10). Analysis of IL-17A was performed using a multiple Bio-Plex immunoassay method. Results. Pregnancy type: the levels of IL-17A were increased in PE compared to N (P=0.0014). Gestational age: the levels of IL-17A were increased in EOPE compared to N group (P=0.0113). A significant increase in the levels of IL-17A in LOPE compared to N was observed (P=0.0063). HIV status: the levels of IL-17A were increased in PE compared to N (P=0.0114) and in EOPE compared to N groups (P=0.0071). HAART duration: the concentration of IL-17A was increased in HAART-chronic PE compared to N groups (P=0.0062). There was also an increase in the levels of IL-17A in EOPE compared to N (P=0.0029). Conclusion. The study demonstrates that IL-17A is involved in the pathophysiology of PE and that in the presence of HIV infection, chronic HAART administration predisposes women to the development of EOPE. |
url |
http://dx.doi.org/10.1155/2020/3417632 |
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