Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients
Abstract Background Among the different types of cancer, pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is the most lethal malignancy, with poor early detection rates and prognosis. The aim of the present study was to investigate the potential genetic effects of the single‐...
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doaj-499154767083468783ebea09ed4f445e2020-11-25T03:20:13ZengWileyMolecular Genetics & Genomic Medicine2324-92692020-06-0186n/an/a10.1002/mgg3.1226Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patientsBaohuan Li0Chuanzhen Zhang1Jingjing Wang2Meijuan Zhang3Changhong Liu4Ziping Chen5Department of Gastroenterology Shandong Provincial Qianfoshan Hospital Shandong University Jinan ChinaDepartment of Gastroenterology The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan ChinaClinical Laboratory The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan ChinaDepartment of Gastroenterology The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan ChinaDepartment of Gastroenterology The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan ChinaDepartment of Gastroenterology The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan ChinaAbstract Background Among the different types of cancer, pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is the most lethal malignancy, with poor early detection rates and prognosis. The aim of the present study was to investigate the potential genetic effects of the single‐nucleotide polymorphisms (SNPs) in ABCB1 (rs1045642, rs3789243, rs4148737), APOB (rs693, rs1042031), CAV1 (rs12672038, rs1997623, rs3807987, rs7804372), and NAMPT (rs9034, rs2505568, rs61330082) on PDAC. Methods A total of 273 patients with PDAC and 263 healthy controls were genotyped using PCR and direct Sanger sequencing. Unconditional logistic regression models were used to evaluate the potential effects of the genotypes, alleles, and haplotypes on the risk of developing PDAC. Results Patients with PDAC possessed a considerably lower frequency of genotypes AG, GG, and allele G at ABCB1 rs4148737 compared with controls. Based on age, sex, smoking status, drinking status, diabetes, and family history of cancer, stratified analyses showed a significant correlation between SNPs at rs4148737 and PDAC. According to specific SNPs, eight haplotypes were constructed along with ABCB1 rs4148737, rs1045642, and rs3789243. Carriers with haplotypes ACC and ATC were more susceptible to developing PDAC, whereas haplotypes GCC and GTC were associated with a reduced likelihood of developing PDAC. The distributions of the other SNPs in each group were not significantly associated with PDAC risk. Conclusions These results suggested that genetic polymorphisms of ABCB1 rs4148737 may influence an individual's risk of developing PDAC.https://doi.org/10.1002/mgg3.1226ABCB1APOBCAV1genetic polymorphismNAMPTpancreatic ductal adenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Baohuan Li Chuanzhen Zhang Jingjing Wang Meijuan Zhang Changhong Liu Ziping Chen |
spellingShingle |
Baohuan Li Chuanzhen Zhang Jingjing Wang Meijuan Zhang Changhong Liu Ziping Chen Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients Molecular Genetics & Genomic Medicine ABCB1 APOB CAV1 genetic polymorphism NAMPT pancreatic ductal adenocarcinoma |
author_facet |
Baohuan Li Chuanzhen Zhang Jingjing Wang Meijuan Zhang Changhong Liu Ziping Chen |
author_sort |
Baohuan Li |
title |
Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients |
title_short |
Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients |
title_full |
Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients |
title_fullStr |
Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients |
title_full_unstemmed |
Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients |
title_sort |
impact of genetic variants of abcb1, apob, cav1, and nampt on susceptibility to pancreatic ductal adenocarcinoma in chinese patients |
publisher |
Wiley |
series |
Molecular Genetics & Genomic Medicine |
issn |
2324-9269 |
publishDate |
2020-06-01 |
description |
Abstract Background Among the different types of cancer, pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is the most lethal malignancy, with poor early detection rates and prognosis. The aim of the present study was to investigate the potential genetic effects of the single‐nucleotide polymorphisms (SNPs) in ABCB1 (rs1045642, rs3789243, rs4148737), APOB (rs693, rs1042031), CAV1 (rs12672038, rs1997623, rs3807987, rs7804372), and NAMPT (rs9034, rs2505568, rs61330082) on PDAC. Methods A total of 273 patients with PDAC and 263 healthy controls were genotyped using PCR and direct Sanger sequencing. Unconditional logistic regression models were used to evaluate the potential effects of the genotypes, alleles, and haplotypes on the risk of developing PDAC. Results Patients with PDAC possessed a considerably lower frequency of genotypes AG, GG, and allele G at ABCB1 rs4148737 compared with controls. Based on age, sex, smoking status, drinking status, diabetes, and family history of cancer, stratified analyses showed a significant correlation between SNPs at rs4148737 and PDAC. According to specific SNPs, eight haplotypes were constructed along with ABCB1 rs4148737, rs1045642, and rs3789243. Carriers with haplotypes ACC and ATC were more susceptible to developing PDAC, whereas haplotypes GCC and GTC were associated with a reduced likelihood of developing PDAC. The distributions of the other SNPs in each group were not significantly associated with PDAC risk. Conclusions These results suggested that genetic polymorphisms of ABCB1 rs4148737 may influence an individual's risk of developing PDAC. |
topic |
ABCB1 APOB CAV1 genetic polymorphism NAMPT pancreatic ductal adenocarcinoma |
url |
https://doi.org/10.1002/mgg3.1226 |
work_keys_str_mv |
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