Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB.

Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB.

The Clostridium difficile exotoxin, TcdB, which is a major virulence factor, varies between strains of this pathogen. Herein, we show that TcdB from the epidemic BI/NAP1/027 strain of C. difficile is more lethal, causes more extensive brain hemorrhage, and is antigenically variable from TcdB produce...

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Bibliographic Details
Main Authors: Jordi M Lanis, Latisha D Heinlen, Judith A James, Jimmy D Ballard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3731247?pdf=render

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