Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study
Abstract Objective In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The...
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doaj-49a23801bb2c4aa29e12ef4acdc4e8112021-02-07T12:44:15ZengBMCBMC Research Notes1756-05002021-02-011411810.1186/s13104-021-05463-5Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot studyThomas Olsen0Bente Øvrebø1Cheryl Turner2Nasser E. Bastani3Helga Refsum4Kathrine J. Vinknes5Department of Nutrition, Institute of Medical Biosciences, Domus Medica, University of OsloDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of OsloDepartment of Pharmacology, University of OxfordDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of OsloDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of OsloDepartment of Nutrition, Institute of Medical Biosciences, Domus Medica, University of OsloAbstract Objective In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow + PUFA diet vs. Met/Cyshigh + SFA. Results The diet groups consisted of five women and two men, aged 20–38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cyslow + PUFA group. In the Met/Cyshigh + SFA group, median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The responses in the amino acid profiles were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7. Trial registration ClinicalTrials.gov: NCT02647970, registration date: January 6th 2016.https://doi.org/10.1186/s13104-021-05463-5Methionine restrictionCysteine restrictionOral glucose toleranceSCDFatty acidsPyruvate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Olsen Bente Øvrebø Cheryl Turner Nasser E. Bastani Helga Refsum Kathrine J. Vinknes |
spellingShingle |
Thomas Olsen Bente Øvrebø Cheryl Turner Nasser E. Bastani Helga Refsum Kathrine J. Vinknes Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study BMC Research Notes Methionine restriction Cysteine restriction Oral glucose tolerance SCD Fatty acids Pyruvate |
author_facet |
Thomas Olsen Bente Øvrebø Cheryl Turner Nasser E. Bastani Helga Refsum Kathrine J. Vinknes |
author_sort |
Thomas Olsen |
title |
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
title_short |
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
title_full |
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
title_fullStr |
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
title_full_unstemmed |
Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
title_sort |
effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2021-02-01 |
description |
Abstract Objective In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow + PUFA diet vs. Met/Cyshigh + SFA. Results The diet groups consisted of five women and two men, aged 20–38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cyslow + PUFA group. In the Met/Cyshigh + SFA group, median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The responses in the amino acid profiles were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7. Trial registration ClinicalTrials.gov: NCT02647970, registration date: January 6th 2016. |
topic |
Methionine restriction Cysteine restriction Oral glucose tolerance SCD Fatty acids Pyruvate |
url |
https://doi.org/10.1186/s13104-021-05463-5 |
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