Boesenbergia rotunda: From Ethnomedicine to Drug Discovery
Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientist...
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doaj-49a60f4a999c40b7a9495684d88e45072020-11-24T23:34:50ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/473637473637Boesenbergia rotunda: From Ethnomedicine to Drug DiscoveryTan Eng-Chong0Lee Yean-Kee1Chee Chin-Fei2Heh Choon-Han3Wong Sher-Ming4Christina Thio Li-Ping5Foo Gen-Teck6Norzulaani Khalid7Noorsaadah Abd Rahman8Saiful Anuar Karsani9Shatrah Othman10Rozana Othman11Rohana Yusof12Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaInstitute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaInstitute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDrug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaBoesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology.http://dx.doi.org/10.1155/2012/473637 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tan Eng-Chong Lee Yean-Kee Chee Chin-Fei Heh Choon-Han Wong Sher-Ming Christina Thio Li-Ping Foo Gen-Teck Norzulaani Khalid Noorsaadah Abd Rahman Saiful Anuar Karsani Shatrah Othman Rozana Othman Rohana Yusof |
spellingShingle |
Tan Eng-Chong Lee Yean-Kee Chee Chin-Fei Heh Choon-Han Wong Sher-Ming Christina Thio Li-Ping Foo Gen-Teck Norzulaani Khalid Noorsaadah Abd Rahman Saiful Anuar Karsani Shatrah Othman Rozana Othman Rohana Yusof Boesenbergia rotunda: From Ethnomedicine to Drug Discovery Evidence-Based Complementary and Alternative Medicine |
author_facet |
Tan Eng-Chong Lee Yean-Kee Chee Chin-Fei Heh Choon-Han Wong Sher-Ming Christina Thio Li-Ping Foo Gen-Teck Norzulaani Khalid Noorsaadah Abd Rahman Saiful Anuar Karsani Shatrah Othman Rozana Othman Rohana Yusof |
author_sort |
Tan Eng-Chong |
title |
Boesenbergia rotunda: From Ethnomedicine to Drug Discovery |
title_short |
Boesenbergia rotunda: From Ethnomedicine to Drug Discovery |
title_full |
Boesenbergia rotunda: From Ethnomedicine to Drug Discovery |
title_fullStr |
Boesenbergia rotunda: From Ethnomedicine to Drug Discovery |
title_full_unstemmed |
Boesenbergia rotunda: From Ethnomedicine to Drug Discovery |
title_sort |
boesenbergia rotunda: from ethnomedicine to drug discovery |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2012-01-01 |
description |
Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology. |
url |
http://dx.doi.org/10.1155/2012/473637 |
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