Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

Epilepsy may result from abnormal function of ion channels, such as those caused by genetic mutations. Recently, pathological alterations of the expression or localization of normal channels have been implicated in epilepsy generation, and termed ‘acquired channelopathies’. Altered expression levels...

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Bibliographic Details
Main Authors:	Cristina Richichi, Amy L. Brewster, Roland A. Bender, Timothy A. Simeone, Qinqin Zha, Hong Z. Yin, John H. Weiss, Tallie Z. Baram
Format:	Article
Language:	English
Published:	Elsevier 2008-02-01
Series:	Neurobiology of Disease
Subjects:	Seizure Epilepsy Ih Hyperpolarization Ion channel HCN channel
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996107002197

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