Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats

Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats

Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (S<sub>BET</sub> ~2700 m<sup>2</sup>/g) was used as a medical...

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Bibliographic Details
Main Authors: Elisaveta Snezhkova, Natalia Rodionova, Dennis Bilko, Joaquin Silvestre-Albero, Alexey Sydorenko, Olga Yurchenko, Margarita Pakharenko, Mo Alavijeh, Kvitoslava Bardakhivska, Natalia Riabchenko, Vladimir Nikolaev
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Applied Sciences
Subjects:
activated charcoal
enterosorbent
acute radiation sickness
rats
Online Access:https://www.mdpi.com/2076-3417/11/7/3174
Description
Summary:Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (S<sub>BET</sub> ~2700 m<sup>2</sup>/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment.
ISSN:2076-3417

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