Generation and trapping of a mesoderm biased state of human pluripotency

Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-s...

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Main Authors:	Dylan Stavish, Charlotta Böiers, Christopher Price, Thomas J. R. Frith, Jason Halliwell, Ingrid Saldaña-Guerrero, Jason Wray, John Brown, Jonathon Carr, Chela James, Ivana Barbaric, Peter W. Andrews, Tariq Enver
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18727-8

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spelling	doaj-49cf589d5cb741e6a087de76d2e334652021-10-10T11:46:29ZengNature Publishing GroupNature Communications2041-17232020-10-0111111610.1038/s41467-020-18727-8Generation and trapping of a mesoderm biased state of human pluripotencyDylan Stavish0Charlotta Böiers1Christopher Price2Thomas J. R. Frith3Jason Halliwell4Ingrid Saldaña-Guerrero5Jason Wray6John Brown7Jonathon Carr8Chela James9Ivana Barbaric10Peter W. Andrews11Tariq Enver12The Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankStem Cell Laboratory, Department of Cancer Biology, University College London Cancer InstituteThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankStem Cell Laboratory, Department of Cancer Biology, University College London Cancer InstituteStem Cell Laboratory, Department of Cancer Biology, University College London Cancer InstituteThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankStem Cell Laboratory, Department of Cancer Biology, University College London Cancer InstituteThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankThe Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western BankStem Cell Laboratory, Department of Cancer Biology, University College London Cancer InstituteApplication of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-state in culture.https://doi.org/10.1038/s41467-020-18727-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver
spellingShingle	Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver Generation and trapping of a mesoderm biased state of human pluripotency Nature Communications
author_facet	Dylan Stavish Charlotta Böiers Christopher Price Thomas J. R. Frith Jason Halliwell Ingrid Saldaña-Guerrero Jason Wray John Brown Jonathon Carr Chela James Ivana Barbaric Peter W. Andrews Tariq Enver
author_sort	Dylan Stavish
title	Generation and trapping of a mesoderm biased state of human pluripotency
title_short	Generation and trapping of a mesoderm biased state of human pluripotency
title_full	Generation and trapping of a mesoderm biased state of human pluripotency
title_fullStr	Generation and trapping of a mesoderm biased state of human pluripotency
title_full_unstemmed	Generation and trapping of a mesoderm biased state of human pluripotency
title_sort	generation and trapping of a mesoderm biased state of human pluripotency
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by identifying and trapping a mesoderm biased sub-state in culture.
url	https://doi.org/10.1038/s41467-020-18727-8
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Generation and trapping of a mesoderm biased state of human pluripotency

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