Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms
MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of h...
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doaj-49d1e907ac864a0da9608729cf6f2cf42021-03-29T23:04:58ZengMDPI AGBiomedicines2227-90592021-03-01934334310.3390/biomedicines9040343Involvement of microRNA in Solid Cancer: Role and Regulatory MechanismsYing-Chin Lin0Tso-Hsiao Chen1Yu-Min Huang2Po-Li Wei3Jung-Chun Lin4Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDivision of Nephrology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanMicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer.https://www.mdpi.com/2227-9059/9/4/343microRNAsolid cancerpost-transcriptional regulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying-Chin Lin Tso-Hsiao Chen Yu-Min Huang Po-Li Wei Jung-Chun Lin |
spellingShingle |
Ying-Chin Lin Tso-Hsiao Chen Yu-Min Huang Po-Li Wei Jung-Chun Lin Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms Biomedicines microRNA solid cancer post-transcriptional regulation |
author_facet |
Ying-Chin Lin Tso-Hsiao Chen Yu-Min Huang Po-Li Wei Jung-Chun Lin |
author_sort |
Ying-Chin Lin |
title |
Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms |
title_short |
Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms |
title_full |
Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms |
title_fullStr |
Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms |
title_full_unstemmed |
Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms |
title_sort |
involvement of microrna in solid cancer: role and regulatory mechanisms |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-03-01 |
description |
MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer. |
topic |
microRNA solid cancer post-transcriptional regulation |
url |
https://www.mdpi.com/2227-9059/9/4/343 |
work_keys_str_mv |
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1724190086638075904 |