Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis
Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively eval...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hong Kong Gold Orchid Science and Technology Co., Limited
2020-01-01
|
Series: | Traditional Medicine Research |
Subjects: | |
Online Access: | https://www.tmrjournals.com/tmr/EN/10.12032/TMR20191228151 |
id |
doaj-49dab477e2fb491fa0cfc75465299e0d |
---|---|
record_format |
Article |
spelling |
doaj-49dab477e2fb491fa0cfc75465299e0d2020-11-24T21:21:05ZengHong Kong Gold Orchid Science and Technology Co., LimitedTraditional Medicine Research2413-39732413-39732020-01-01515361Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysisJia Wang0Zhu Yang1Fengxi Long2Li Luo3Jinlin Wu4Ting Yu5Dongxin Tang6Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China;Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China;Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China;Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001; 4Guihang Guiyang Hospital, Guiyang, 550025, China.Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China;Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China;Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, China; 3Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P = 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P <0.001), inhibited leukopenia (RR = 0.55, 95% CI (0.42, 0.71), P < 0.001), reduced neurotoxicity (RR = 0.43, 95% CI (0.34, 0.56), P < 0.001), and reduced the incidence of nausea and vomiting (RR = 0.67, 95% CI (0.55, 0.80), P < 0.001). Conclusion: Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer.https://www.tmrjournals.com/tmr/EN/10.12032/TMR20191228151astragalus injectioncolorectal canceradjuvant therapymeta-analysisrandomized controlled trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia Wang Zhu Yang Fengxi Long Li Luo Jinlin Wu Ting Yu Dongxin Tang |
spellingShingle |
Jia Wang Zhu Yang Fengxi Long Li Luo Jinlin Wu Ting Yu Dongxin Tang Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis Traditional Medicine Research astragalus injection colorectal cancer adjuvant therapy meta-analysis randomized controlled trial |
author_facet |
Jia Wang Zhu Yang Fengxi Long Li Luo Jinlin Wu Ting Yu Dongxin Tang |
author_sort |
Jia Wang |
title |
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
title_short |
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
title_full |
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
title_fullStr |
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
title_full_unstemmed |
Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
title_sort |
astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis |
publisher |
Hong Kong Gold Orchid Science and Technology Co., Limited |
series |
Traditional Medicine Research |
issn |
2413-3973 2413-3973 |
publishDate |
2020-01-01 |
description |
Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P = 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P <0.001), inhibited leukopenia (RR = 0.55, 95% CI (0.42, 0.71), P < 0.001), reduced neurotoxicity (RR = 0.43, 95% CI (0.34, 0.56), P < 0.001), and reduced the incidence of nausea and vomiting (RR = 0.67, 95% CI (0.55, 0.80), P < 0.001). Conclusion: Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer. |
topic |
astragalus injection colorectal cancer adjuvant therapy meta-analysis randomized controlled trial |
url |
https://www.tmrjournals.com/tmr/EN/10.12032/TMR20191228151 |
work_keys_str_mv |
AT jiawang astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT zhuyang astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT fengxilong astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT liluo astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT jinlinwu astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT tingyu astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis AT dongxintang astragalusinjectionasanadjuvanttreatmentforcolorectalcancerametaanalysis |
_version_ |
1716732352392069120 |