Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy
Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome which impairs quality of cancer patients' life. Cerebrosides, a principal class of sphingolipids, have various biological actions such as anti-tumour effects. In this study, we found that a continuous oral administration of c...
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doaj-49dbfd33234a46acaf42d9c6f0f6e8c92021-04-29T04:44:42ZengElsevierJournal of Functional Foods1756-46462015-08-0117352363Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophyLei Du0Jie Xu1Yong Xue2Koretaro Takahashi3Chang-Hu Xue4Jing-Feng Wang5Yu-Ming Wang6College of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, China; Faculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato-cho, Hakodate, Hokkaido 041-8611, JapanCollege of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, ChinaFaculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato-cho, Hakodate, Hokkaido 041-8611, JapanCollege of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yu-Shan Road, Qingdao, Shandong Province 266003, China; Corresponding author. College of Food Science and Engineering, Ocean University of China, No.5, Yu-Shan Road, Qingdao, Shandong Province 266003, China. Tel.: +86 532 82032597; fax: +86 532 82032468.Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome which impairs quality of cancer patients' life. Cerebrosides, a principal class of sphingolipids, have various biological actions such as anti-tumour effects. In this study, we found that a continuous oral administration of cerebrosides obtained from sea cucumber Acaudina molpadioides (AMC) at 50 mg/kg body mass per day suppressed body weight loss through alleviating adipose atrophy in CAC mice. The possible mechanism by which dietary AMC prevents adipose atrophy in CAC mice was related to reducing serum inflammatory cytokine levels, regulating over-lipolysis, enhancing the function of lipogenesis and decreasing the lipid over-utilization. To elucidate the structure–activity relationships of AMC and its long-chain base (LCB), we also compared the anti-tumour activities between them. The results indicated that LCB exhibited more prominent anti-tumour effect both in vivo and in vitro. Therefore, AMC and its LCB are highly worth developing as novel agents for cancer therapy.http://www.sciencedirect.com/science/article/pii/S1756464615002790CerebrosidesInflammatory cytokinesWhite adipose tissue (WAT)LipolysisLipogenesisLong-chain base |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Du Jie Xu Yong Xue Koretaro Takahashi Chang-Hu Xue Jing-Feng Wang Yu-Ming Wang |
spellingShingle |
Lei Du Jie Xu Yong Xue Koretaro Takahashi Chang-Hu Xue Jing-Feng Wang Yu-Ming Wang Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy Journal of Functional Foods Cerebrosides Inflammatory cytokines White adipose tissue (WAT) Lipolysis Lipogenesis Long-chain base |
author_facet |
Lei Du Jie Xu Yong Xue Koretaro Takahashi Chang-Hu Xue Jing-Feng Wang Yu-Ming Wang |
author_sort |
Lei Du |
title |
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
title_short |
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
title_full |
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
title_fullStr |
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
title_full_unstemmed |
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
title_sort |
cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2015-08-01 |
description |
Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome which impairs quality of cancer patients' life. Cerebrosides, a principal class of sphingolipids, have various biological actions such as anti-tumour effects. In this study, we found that a continuous oral administration of cerebrosides obtained from sea cucumber Acaudina molpadioides (AMC) at 50 mg/kg body mass per day suppressed body weight loss through alleviating adipose atrophy in CAC mice. The possible mechanism by which dietary AMC prevents adipose atrophy in CAC mice was related to reducing serum inflammatory cytokine levels, regulating over-lipolysis, enhancing the function of lipogenesis and decreasing the lipid over-utilization. To elucidate the structure–activity relationships of AMC and its long-chain base (LCB), we also compared the anti-tumour activities between them. The results indicated that LCB exhibited more prominent anti-tumour effect both in vivo and in vitro. Therefore, AMC and its LCB are highly worth developing as novel agents for cancer therapy. |
topic |
Cerebrosides Inflammatory cytokines White adipose tissue (WAT) Lipolysis Lipogenesis Long-chain base |
url |
http://www.sciencedirect.com/science/article/pii/S1756464615002790 |
work_keys_str_mv |
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1721501706362028032 |