A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor–liver crosstalk in causing adverse effects on the host

A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor–liver crosstalk in causing adverse effects on the host

The nature of host organs and genes that underlie tumor-induced physiological disruption on the host remains ill-defined. Here, we establish a novel zebrafish intestinal tumor model that is suitable for addressing this issue, and find that hepatic cyp7a1, the rate-limiting factor for synthesizing bi...

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Bibliographic Details
Main Authors: Sora Enya, Koichi Kawakami, Yutaka Suzuki, Shinpei Kawaoka, Almut Schulze, Mariia Yuneva
Format: Article
Language:English
Published: The Company of Biologists 2018-08-01
Series:Disease Models & Mechanisms
Subjects:
Intestinal tumor
Hepatomegaly
Liver inflammation
Growth defect
cyp7a1
Cholesterol metabolism
Online Access:http://dmm.biologists.org/content/11/8/dmm032383

Internet

http://dmm.biologists.org/content/11/8/dmm032383

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