Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin

Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin

The expression of the leukotoxin of Aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. A 530-bp deletion or an 886-bp insertion sequence (IS) element in this region has earlier been described in highly leukotoxic isolates. Here, we report on highly leukotoxic isolate with...

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Main Authors: Rolf Claesson, Jan Gudmundson, Carola Höglund Åberg, Dorte Haubek, Anders Johansson
Format: Article
Language:English
Published: Taylor & Francis Group 2015-04-01
Series:Journal of Oral Microbiology
Subjects:
leukotoxicity
deletion
JP2
aggressive periodontitis
geographic spreading
Africa
Online Access:http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26974/39571
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spelling doaj-4a041a09f05b46dab75d49c8e9bad4622020-11-24T22:51:51ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972015-04-01701410.3402/jom.v7.2697426974Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian originRolf Claesson0Jan Gudmundson1Carola Höglund Åberg2Dorte Haubek3Anders Johansson4 Division of Oral Microbiology, Department of Odontology, Umeå University, Umeå, Sweden Periodontology Specialist Clinic, Östersunds Hospital, Östersund, Sweden Division of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, Sweden Section for Pediatric Dentistry, Department of Dentistry, Health, Aarhus University, Aarhus, Denmark Division of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, SwedenThe expression of the leukotoxin of Aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. A 530-bp deletion or an 886-bp insertion sequence (IS) element in this region has earlier been described in highly leukotoxic isolates. Here, we report on highly leukotoxic isolate with a 640-bp deletion, which was detected in an adolescent of Ethiopian origin.http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26974/39571leukotoxicitydeletionJP2aggressive periodontitisgeographic spreadingAfrica
collection DOAJ
language English
format Article
sources DOAJ
author Rolf Claesson
Jan Gudmundson
Carola Höglund Åberg
Dorte Haubek
Anders Johansson
spellingShingle Rolf Claesson
Jan Gudmundson
Carola Höglund Åberg
Dorte Haubek
Anders Johansson
Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
Journal of Oral Microbiology
leukotoxicity
deletion
JP2
aggressive periodontitis
geographic spreading
Africa
author_facet Rolf Claesson
Jan Gudmundson
Carola Höglund Åberg
Dorte Haubek
Anders Johansson
author_sort Rolf Claesson
title Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
title_short Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
title_full Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
title_fullStr Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
title_full_unstemmed Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin
title_sort detection of a 640-bp deletion in the aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of ethiopian origin
publisher Taylor & Francis Group
series Journal of Oral Microbiology
issn 2000-2297
publishDate 2015-04-01
description The expression of the leukotoxin of Aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. A 530-bp deletion or an 886-bp insertion sequence (IS) element in this region has earlier been described in highly leukotoxic isolates. Here, we report on highly leukotoxic isolate with a 640-bp deletion, which was detected in an adolescent of Ethiopian origin.
topic leukotoxicity
deletion
JP2
aggressive periodontitis
geographic spreading
Africa
url http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26974/39571
work_keys_str_mv AT rolfclaesson detectionofa640bpdeletionintheaggregatibacteractinomycetemcomitansleukotoxinpromoterregioninisolatesfromanadolescentofethiopianorigin
AT jangudmundson detectionofa640bpdeletionintheaggregatibacteractinomycetemcomitansleukotoxinpromoterregioninisolatesfromanadolescentofethiopianorigin
AT carolahoglundaberg detectionofa640bpdeletionintheaggregatibacteractinomycetemcomitansleukotoxinpromoterregioninisolatesfromanadolescentofethiopianorigin
AT dortehaubek detectionofa640bpdeletionintheaggregatibacteractinomycetemcomitansleukotoxinpromoterregioninisolatesfromanadolescentofethiopianorigin
AT andersjohansson detectionofa640bpdeletionintheaggregatibacteractinomycetemcomitansleukotoxinpromoterregioninisolatesfromanadolescentofethiopianorigin
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