Alpha-synuclein structure, functions, and interactions
At present, when a clinical diagnosis of Parkinson′s disease (PD) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. The diagnosis of PD in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategi...
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doaj-4a04eea2c9cf4fa587be134e622882ba2020-11-24T20:56:49ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362016-01-01211292910.4103/1735-1995.181989Alpha-synuclein structure, functions, and interactionsFatemeh Nouri EmamzadehAt present, when a clinical diagnosis of Parkinson′s disease (PD) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. The diagnosis of PD in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation of toxic aggregates. As a molecular biomarker for the detection of PD in its earlier stages, alpha-synuclein (α-syn), which is a key component of Lewy bodies, in which it is found in an aggregated and fibrillar form, has attracted considerable attention. Here, α-syn is reviewed in details.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=29;epage=29;aulast=EmamzadehAlpha-synucleinbiomarkerParkinson′s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Nouri Emamzadeh |
spellingShingle |
Fatemeh Nouri Emamzadeh Alpha-synuclein structure, functions, and interactions Journal of Research in Medical Sciences Alpha-synuclein biomarker Parkinson′s disease |
author_facet |
Fatemeh Nouri Emamzadeh |
author_sort |
Fatemeh Nouri Emamzadeh |
title |
Alpha-synuclein structure, functions, and interactions |
title_short |
Alpha-synuclein structure, functions, and interactions |
title_full |
Alpha-synuclein structure, functions, and interactions |
title_fullStr |
Alpha-synuclein structure, functions, and interactions |
title_full_unstemmed |
Alpha-synuclein structure, functions, and interactions |
title_sort |
alpha-synuclein structure, functions, and interactions |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2016-01-01 |
description |
At present, when a clinical diagnosis of Parkinson′s disease (PD) is made, serious damage has already been done to nerve cells of the substantia nigra pars compacta. The diagnosis of PD in its earlier stages, before this irreversible damage, would be of enormous benefit for future treatment strategies designed to slow or halt the progression of this disease that possibly prevents accumulation of toxic aggregates. As a molecular biomarker for the detection of PD in its earlier stages, alpha-synuclein (α-syn), which is a key component of Lewy bodies, in which it is found in an aggregated and fibrillar form, has attracted considerable attention. Here, α-syn is reviewed in details. |
topic |
Alpha-synuclein biomarker Parkinson′s disease |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=29;epage=29;aulast=Emamzadeh |
work_keys_str_mv |
AT fatemehnouriemamzadeh alphasynucleinstructurefunctionsandinteractions |
_version_ |
1716789657781403648 |