Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection

Background: We aimed to evaluate the impact of knee periprosthetic joint infection (PJI) by assessing the patients’ long-term quality of life and explicitly their psychological wellbeing after successful treatment. Methods: Thirty-six patients with achieved eradication of infection after knee PJI we...

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Main Authors: Nike Walter, Markus Rupp, Katja Hierl, Matthias Koch, Maximilian Kerschbaum, Michael Worlicek, Volker Alt
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/10/5/907
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spelling doaj-4a08c12c8fef47399dba5cef316b96382021-02-26T00:04:50ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-011090790710.3390/jcm10050907Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint InfectionNike Walter0Markus Rupp1Katja Hierl2Matthias Koch3Maximilian Kerschbaum4Michael Worlicek5Volker Alt6Department for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment for Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, GermanyBackground: We aimed to evaluate the impact of knee periprosthetic joint infection (PJI) by assessing the patients’ long-term quality of life and explicitly their psychological wellbeing after successful treatment. Methods: Thirty-six patients with achieved eradication of infection after knee PJI were included. Quality of life was evaluated with the EQ-5D and SF-36 outcome instruments as well as with an ICD-10 based symptom rating (ISR) and compared to normative data. Results: At a follow-up of 4.9 ± 3.5 years the mean SF-36 score was 24.82 ± 10.0 regarding the physical health component and 46.16 ± 13.3 regarding the mental health component compared to German normative values of 48.36 ± 9.4 (<i>p</i> < 0.001) and 50.87 ± 8.8 (<i>p</i> = 0.003). The mean EQ-5D index reached 0.55 ± 0.33 with an EQ-5D VAS rating of 52.14 ± 19.9 compared to reference scores of 0.891 (<i>p</i> < 0.001) and 68.6 ± 1.1 (<i>p</i> < 0.001). Mean scores of the ISR revealed the psychological symptom burden on the depression scale. Conclusion: PJI patients still suffer from significantly lower quality of life compared to normative data, even years after surgically successful treatment. Future clinical studies should focus on patient-related outcome measures. Newly emerging treatment strategies, prevention methods, and interdisciplinary approaches should be implemented to improve the quality of life of PJI patients.https://www.mdpi.com/2077-0383/10/5/907quality of lifeperiprosthetic joint infectionrevision arthroplastypsychological outcomes
collection DOAJ
language English
format Article
sources DOAJ
author Nike Walter
Markus Rupp
Katja Hierl
Matthias Koch
Maximilian Kerschbaum
Michael Worlicek
Volker Alt
spellingShingle Nike Walter
Markus Rupp
Katja Hierl
Matthias Koch
Maximilian Kerschbaum
Michael Worlicek
Volker Alt
Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
Journal of Clinical Medicine
quality of life
periprosthetic joint infection
revision arthroplasty
psychological outcomes
author_facet Nike Walter
Markus Rupp
Katja Hierl
Matthias Koch
Maximilian Kerschbaum
Michael Worlicek
Volker Alt
author_sort Nike Walter
title Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
title_short Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
title_full Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
title_fullStr Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
title_full_unstemmed Long-Term Patient-Related Quality of Life after Knee Periprosthetic Joint Infection
title_sort long-term patient-related quality of life after knee periprosthetic joint infection
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2021-02-01
description Background: We aimed to evaluate the impact of knee periprosthetic joint infection (PJI) by assessing the patients’ long-term quality of life and explicitly their psychological wellbeing after successful treatment. Methods: Thirty-six patients with achieved eradication of infection after knee PJI were included. Quality of life was evaluated with the EQ-5D and SF-36 outcome instruments as well as with an ICD-10 based symptom rating (ISR) and compared to normative data. Results: At a follow-up of 4.9 ± 3.5 years the mean SF-36 score was 24.82 ± 10.0 regarding the physical health component and 46.16 ± 13.3 regarding the mental health component compared to German normative values of 48.36 ± 9.4 (<i>p</i> < 0.001) and 50.87 ± 8.8 (<i>p</i> = 0.003). The mean EQ-5D index reached 0.55 ± 0.33 with an EQ-5D VAS rating of 52.14 ± 19.9 compared to reference scores of 0.891 (<i>p</i> < 0.001) and 68.6 ± 1.1 (<i>p</i> < 0.001). Mean scores of the ISR revealed the psychological symptom burden on the depression scale. Conclusion: PJI patients still suffer from significantly lower quality of life compared to normative data, even years after surgically successful treatment. Future clinical studies should focus on patient-related outcome measures. Newly emerging treatment strategies, prevention methods, and interdisciplinary approaches should be implemented to improve the quality of life of PJI patients.
topic quality of life
periprosthetic joint infection
revision arthroplasty
psychological outcomes
url https://www.mdpi.com/2077-0383/10/5/907
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