Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice
Objective: No study has comprehensively evaluated the effect of postweaning isolation on the social and sexual behaviors of a certain strain of rodents in ethology. The present study aims to explore how and to what extent isolation rearing after postweaning affects the social and sexual behaviors of...
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Frontiers Media S.A.
2019-02-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00021/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zi-Wei Liu Zi-Wei Liu Zi-Wei Liu Yu Yu Cong Lu Ning Jiang Xiao-Ping Wang Xiao-Ping Wang Shui-Yuan Xiao Shui-Yuan Xiao Shui-Yuan Xiao Xin-Min Liu |
spellingShingle |
Zi-Wei Liu Zi-Wei Liu Zi-Wei Liu Yu Yu Cong Lu Ning Jiang Xiao-Ping Wang Xiao-Ping Wang Shui-Yuan Xiao Shui-Yuan Xiao Shui-Yuan Xiao Xin-Min Liu Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice Frontiers in Behavioral Neuroscience postweaning isolation rearing social behavior sexual preference mating behavior male CD-1 mice |
author_facet |
Zi-Wei Liu Zi-Wei Liu Zi-Wei Liu Yu Yu Cong Lu Ning Jiang Xiao-Ping Wang Xiao-Ping Wang Shui-Yuan Xiao Shui-Yuan Xiao Shui-Yuan Xiao Xin-Min Liu |
author_sort |
Zi-Wei Liu |
title |
Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice |
title_short |
Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice |
title_full |
Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice |
title_fullStr |
Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice |
title_full_unstemmed |
Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice |
title_sort |
postweaning isolation rearing alters the adult social, sexual preference and mating behaviors of male cd-1 mice |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2019-02-01 |
description |
Objective: No study has comprehensively evaluated the effect of postweaning isolation on the social and sexual behaviors of a certain strain of rodents in ethology. The present study aims to explore how and to what extent isolation rearing after postweaning affects the social and sexual behaviors of male CD-1 mice in adulthood systematically.Methods: Male CD-1 mice were randomly assigned to two groups: isolation reared (IS, one mouse per cage, n = 30) and group housed (GH, five mice per cage, n = 15). The mice underwent isolation rearing from postnatal day 23 to day 93. Then, social affiliation, recognition and memory were measured through selection task experiments. Social interaction under a home cage and novel environment were measured via resident–intruder and social interaction test, respectively. Furthermore, sexual preference, homosexual and heterosexual behaviors were measured.Results: Our study found that postweaning isolation increased the social affiliation for conspecifics (p = 0.001), reduced social recognition (p = 0.042) and impaired social memory. As for social interaction, isolated mice showed a remarkably increased aggression toward the intruder male in a home cage or novelty environment. For instance, isolated mice presented a short attack latency (p < 0.001), high attack frequency (p < 0.001) and long attack duration (p < 0.001). In addition, isolated mice exhibited further social avoidance. Contrastingly, isolated mice displayed a reduced sexual preference for female (IS: 61.47 ± 13.80%, GH: 70.33 ± 10.06%, p = 0.038). As for heterosexual behavior, isolated mice have a short mating duration (p = 0.002), long mounting latency (p = 0.002), and long intromission latency (p = 0.015). However, no association was observed between postweaning isolation and homosexual behavior in male CD-1 mouse.Conclusion: Postweaning isolation increased the social affiliation, impaired the social cognition and considerably increased the aggression in social interaction of adult male CD-1 mice. Postweaning isolation induced a decreased sexual preference for female in adulthood. Postweaning isolation extended the latency to mate, thereby reducing mating behavior. No association was observed between isolation and homosexual behavior. |
topic |
postweaning isolation rearing social behavior sexual preference mating behavior male CD-1 mice |
url |
https://www.frontiersin.org/article/10.3389/fnbeh.2019.00021/full |
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doaj-4a0ab9f5394c4d9b8339919db2494a1d2020-11-24T21:41:35ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-02-011310.3389/fnbeh.2019.00021422195Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 MiceZi-Wei Liu0Zi-Wei Liu1Zi-Wei Liu2Yu Yu3Cong Lu4Ning Jiang5Xiao-Ping Wang6Xiao-Ping Wang7Shui-Yuan Xiao8Shui-Yuan Xiao9Shui-Yuan Xiao10Xin-Min Liu11Department of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders and National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaResearch Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaResearch Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders and National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry and Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders and National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaResearch Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaObjective: No study has comprehensively evaluated the effect of postweaning isolation on the social and sexual behaviors of a certain strain of rodents in ethology. The present study aims to explore how and to what extent isolation rearing after postweaning affects the social and sexual behaviors of male CD-1 mice in adulthood systematically.Methods: Male CD-1 mice were randomly assigned to two groups: isolation reared (IS, one mouse per cage, n = 30) and group housed (GH, five mice per cage, n = 15). The mice underwent isolation rearing from postnatal day 23 to day 93. Then, social affiliation, recognition and memory were measured through selection task experiments. Social interaction under a home cage and novel environment were measured via resident–intruder and social interaction test, respectively. Furthermore, sexual preference, homosexual and heterosexual behaviors were measured.Results: Our study found that postweaning isolation increased the social affiliation for conspecifics (p = 0.001), reduced social recognition (p = 0.042) and impaired social memory. As for social interaction, isolated mice showed a remarkably increased aggression toward the intruder male in a home cage or novelty environment. For instance, isolated mice presented a short attack latency (p < 0.001), high attack frequency (p < 0.001) and long attack duration (p < 0.001). In addition, isolated mice exhibited further social avoidance. Contrastingly, isolated mice displayed a reduced sexual preference for female (IS: 61.47 ± 13.80%, GH: 70.33 ± 10.06%, p = 0.038). As for heterosexual behavior, isolated mice have a short mating duration (p = 0.002), long mounting latency (p = 0.002), and long intromission latency (p = 0.015). However, no association was observed between postweaning isolation and homosexual behavior in male CD-1 mouse.Conclusion: Postweaning isolation increased the social affiliation, impaired the social cognition and considerably increased the aggression in social interaction of adult male CD-1 mice. Postweaning isolation induced a decreased sexual preference for female in adulthood. Postweaning isolation extended the latency to mate, thereby reducing mating behavior. No association was observed between isolation and homosexual behavior.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00021/fullpostweaningisolation rearingsocial behaviorsexual preferencemating behaviormale CD-1 mice |