Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response. Expression of AID is tightly regulated due to its mutagenic and recombinogenic potential, which is...
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doaj-4a1940537fd74daa89966a138405a1612020-11-25T00:32:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-12-01510.3389/fimmu.2014.00642121890Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesisPilar M Dominguez0Rita eShaknovich1Rita eShaknovich2Weill Cornell Medical CollegeWeill Cornell Medical CollegeWeill Cornell Medical CollegeActivation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response. Expression of AID is tightly regulated due to its mutagenic and recombinogenic potential, which is known to target not only Ig genes, but also non-Ig genes, contributing to lymphomagenesis. In recent years a new epigenetic function of AID and its link to DNA demethylation came to light in several developmental systems. In this review, we summarize existing evidence linking deamination of unmodified and modified cytidine by AID to base-excision repair (BER) and mismatch repair (MMR) machinery resulting in passive or active removal of DNA methylation mark, with the focus on B cell biology. We also discuss potential contribution of AID-dependent DNA hypomethylation to lymphomagenesis.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00642/fullDNA MethylationepigeneticsB cellsactivation-induced cytidine deaminase (AID)Lymphomagenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pilar M Dominguez Rita eShaknovich Rita eShaknovich |
spellingShingle |
Pilar M Dominguez Rita eShaknovich Rita eShaknovich Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis Frontiers in Immunology DNA Methylation epigenetics B cells activation-induced cytidine deaminase (AID) Lymphomagenesis |
author_facet |
Pilar M Dominguez Rita eShaknovich Rita eShaknovich |
author_sort |
Pilar M Dominguez |
title |
Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis |
title_short |
Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis |
title_full |
Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis |
title_fullStr |
Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis |
title_full_unstemmed |
Epigenetic function of Activation-Induced Cytidine Deaminase (AID) and its link to lymphomagenesis |
title_sort |
epigenetic function of activation-induced cytidine deaminase (aid) and its link to lymphomagenesis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2014-12-01 |
description |
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes during B cell maturation and immune response. Expression of AID is tightly regulated due to its mutagenic and recombinogenic potential, which is known to target not only Ig genes, but also non-Ig genes, contributing to lymphomagenesis. In recent years a new epigenetic function of AID and its link to DNA demethylation came to light in several developmental systems. In this review, we summarize existing evidence linking deamination of unmodified and modified cytidine by AID to base-excision repair (BER) and mismatch repair (MMR) machinery resulting in passive or active removal of DNA methylation mark, with the focus on B cell biology. We also discuss potential contribution of AID-dependent DNA hypomethylation to lymphomagenesis. |
topic |
DNA Methylation epigenetics B cells activation-induced cytidine deaminase (AID) Lymphomagenesis |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00642/full |
work_keys_str_mv |
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