Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives

Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives

Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones. Chalcones refluxed with substituted acid hydrazides to afford different indoloquinoxali...

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Main Authors: CH. Sridevi, K. Balaji, A. Naidu
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2011/584817
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spelling doaj-4a1df71f8c55477192caae77dcf76fd72020-11-24T22:02:19ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102011-01-018292493010.1155/2011/584817Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline DerivativesCH. Sridevi0K. Balaji1A. Naidu2Dept. of Pharmaceutical Chemistry, Geethanjali College of Pharmacy Cheeryal(V), Keesara(M), Hyderabad, 501301, IndiaDept. of Pharmaceutical Chemistry, Geethanjali College of Pharmacy Cheeryal(V), Keesara(M), Hyderabad, 501301, IndiaDept. of Pharmaceutical Chemistry, Geethanjali College of Pharmacy Cheeryal(V), Keesara(M), Hyderabad, 501301, IndiaIndoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones. Chalcones refluxed with substituted acid hydrazides to afford different indoloquinoxaline pyrazolines. The structure of chalcones and indoloquinoxaline pyrazolines were confirmed by M.P, TLC and spectral data. All the synthesized compounds were screened for their antioxidant, anti-inflammatory and antihistamic activities.http://dx.doi.org/10.1155/2011/584817
collection DOAJ
language English
format Article
sources DOAJ
author CH. Sridevi
K. Balaji
A. Naidu
spellingShingle CH. Sridevi
K. Balaji
A. Naidu
Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
E-Journal of Chemistry
author_facet CH. Sridevi
K. Balaji
A. Naidu
author_sort CH. Sridevi
title Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
title_short Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
title_full Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
title_fullStr Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
title_full_unstemmed Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives
title_sort synthesis and pharmacological evaluation of some phenylpyrazolo indoquinoxaline derivatives
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2011-01-01
description Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones. Chalcones refluxed with substituted acid hydrazides to afford different indoloquinoxaline pyrazolines. The structure of chalcones and indoloquinoxaline pyrazolines were confirmed by M.P, TLC and spectral data. All the synthesized compounds were screened for their antioxidant, anti-inflammatory and antihistamic activities.
url http://dx.doi.org/10.1155/2011/584817
work_keys_str_mv AT chsridevi synthesisandpharmacologicalevaluationofsomephenylpyrazoloindoquinoxalinederivatives
AT kbalaji synthesisandpharmacologicalevaluationofsomephenylpyrazoloindoquinoxalinederivatives
AT anaidu synthesisandpharmacologicalevaluationofsomephenylpyrazoloindoquinoxalinederivatives
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