Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery

Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery

An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine...

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Bibliographic Details
Main Authors: Alberto Utrero-Rico, Cecilia González-Cuadrado, Marta Chivite-Lacaba, Oscar Cabrera-Marante, Rocío Laguna-Goya, Patricia Almendro-Vazquez, Carmen Díaz-Pedroche, María Ruiz-Ruigómez, Antonio Lalueza, María Dolores Folgueira, Enrique Vázquez, Ana Quintas, Marcos J. Berges-Buxeda, Moisés Martín-Rodriguez, Ana Dopazo, Antonio Serrano-Hernández, José María Aguado, Estela Paz-Artal
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
circulating monocytes
COVID-19
HLA-DR
transcriptome
chromatin accessibility
Online Access:https://www.mdpi.com/2227-9059/9/9/1253

Internet

https://www.mdpi.com/2227-9059/9/9/1253

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