Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

Sigma-1 receptor knockout (σ1R-KO) mice exhibit a depressive-like phenotype. Because σ1R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN), this study investigated the influence of σ1R deficiency on the regulation of the hypothalamic-pituitary-adrenocortical (HPA...

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Bibliographic Details
Main Authors:	Tingting Di, Suyun Zhang, Juan Hong, Tingting Zhang, Ling Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-09-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	sigma-1 receptor (σ1R) hypothalamic-pituitary-adrenal (HPA) axis glucocorticoid receptor (GR) protein kinase C (PKC) depression
Online Access:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00287/full

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