Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology
Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, incre...
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doaj-4a3c9090335146c9b493f94de0d1e2b02020-11-25T03:46:30ZengSAGE PublishingDose-Response1559-32582020-07-011810.1177/1559325820936161Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for OncologyLina Yan0Jingjing Shen1Jinqiao Wang2Xiaoyan Yang3Shiyan Dong4Saijun Lu5 Department of Rehabilitation Medicine, The First People’s Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China School of Civil Engineering and Architecture, Taizhou University, Taizhou, Zhejiang, China Department of Rehabilitation Medicine, The First People’s Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China Department of Rehabilitation Medicine, The First People’s Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China School of Life Sciences, Jilin University, Changchun, Jilin, China Department of Rehabilitation Medicine, The First People’s Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, ChinaChemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities.https://doi.org/10.1177/1559325820936161 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lina Yan Jingjing Shen Jinqiao Wang Xiaoyan Yang Shiyan Dong Saijun Lu |
spellingShingle |
Lina Yan Jingjing Shen Jinqiao Wang Xiaoyan Yang Shiyan Dong Saijun Lu Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology Dose-Response |
author_facet |
Lina Yan Jingjing Shen Jinqiao Wang Xiaoyan Yang Shiyan Dong Saijun Lu |
author_sort |
Lina Yan |
title |
Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology |
title_short |
Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology |
title_full |
Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology |
title_fullStr |
Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology |
title_full_unstemmed |
Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology |
title_sort |
nanoparticle-based drug delivery system: a patient-friendly chemotherapy for oncology |
publisher |
SAGE Publishing |
series |
Dose-Response |
issn |
1559-3258 |
publishDate |
2020-07-01 |
description |
Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities. |
url |
https://doi.org/10.1177/1559325820936161 |
work_keys_str_mv |
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