Programmed cell senescence in skeleton during late puberty
Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.
Bibliographic Details
Main Authors: |
Changjun Li,
Yu Chai,
Lei Wang,
Bo Gao,
Hao Chen,
Peisong Gao,
Feng-Quan Zhou,
Xianghang Luo,
Janet L. Crane,
Bin Yu,
Xu Cao,
Mei Wan |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-11-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/s41467-017-01509-0
|