PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1

PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1

High mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target. Of particular interest is t...

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Main Authors: Shibo Ying, Xiang Xiao, Tianhui Chen, Jianlin Lou
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2016/2612743
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spelling doaj-4a4866a5ac414f8eb325e7221c6727de2020-11-24T22:36:10ZengHindawi LimitedPPAR Research1687-47571687-47652016-01-01201610.1155/2016/26127432612743PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1Shibo Ying0Xiang Xiao1Tianhui Chen2Jianlin Lou3Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaDepartment of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaInstitute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaInstitute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaHigh mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target. Of particular interest is the fact that certain PPAR ligands have demonstrated their potent anti-inflammatory activities and potential anticancer effects. In this review article we summarize recent experimental evidence that PPAR ligands function as suppressors that target biological actions of HMGB1, including intracellular expression, receptor signaling cascades, and extracellular secretion of HMGB1 in cell lines and/or animal models. We also propose the possible mechanisms underlying PPAR involvement in inflammatory disorders and discuss the future therapeutic value of PPAR ligands targeting HMGB1 molecule for cancer prevention and treatment.http://dx.doi.org/10.1155/2016/2612743
collection DOAJ
language English
format Article
sources DOAJ
author Shibo Ying
Xiang Xiao
Tianhui Chen
Jianlin Lou
spellingShingle Shibo Ying
Xiang Xiao
Tianhui Chen
Jianlin Lou
PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
PPAR Research
author_facet Shibo Ying
Xiang Xiao
Tianhui Chen
Jianlin Lou
author_sort Shibo Ying
title PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
title_short PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
title_full PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
title_fullStr PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
title_full_unstemmed PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
title_sort ppar ligands function as suppressors that target biological actions of hmgb1
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2016-01-01
description High mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target. Of particular interest is the fact that certain PPAR ligands have demonstrated their potent anti-inflammatory activities and potential anticancer effects. In this review article we summarize recent experimental evidence that PPAR ligands function as suppressors that target biological actions of HMGB1, including intracellular expression, receptor signaling cascades, and extracellular secretion of HMGB1 in cell lines and/or animal models. We also propose the possible mechanisms underlying PPAR involvement in inflammatory disorders and discuss the future therapeutic value of PPAR ligands targeting HMGB1 molecule for cancer prevention and treatment.
url http://dx.doi.org/10.1155/2016/2612743
work_keys_str_mv AT shiboying pparligandsfunctionassuppressorsthattargetbiologicalactionsofhmgb1
AT xiangxiao pparligandsfunctionassuppressorsthattargetbiologicalactionsofhmgb1
AT tianhuichen pparligandsfunctionassuppressorsthattargetbiologicalactionsofhmgb1
AT jianlinlou pparligandsfunctionassuppressorsthattargetbiologicalactionsofhmgb1
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