Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes

Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes

The heart has two intrinsic mechanisms to enhance contractile strength that compensate for increased mechanical load to help maintain cardiac output. When vascular resistance increases the ventricular chamber initially expands causing an immediate length-dependent increase of contraction force via t...

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Bibliographic Details
Main Authors: Leighton Izu, Rafael Shimkunas, Zhong Jian, Bence Hegyi, Mohammad Kazemi-Lari, Anthony Baker, John Shaw, Tamas Banyasz, Ye Chen-Izu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Life
Subjects:
autoregulation
contractility
cardiomyocyte
Anrep effect
mathematical analysis
mathematical model
Online Access:https://www.mdpi.com/2075-1729/11/6/503

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