Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes
The heart has two intrinsic mechanisms to enhance contractile strength that compensate for increased mechanical load to help maintain cardiac output. When vascular resistance increases the ventricular chamber initially expands causing an immediate length-dependent increase of contraction force via t...
Main Authors: | Leighton Izu, Rafael Shimkunas, Zhong Jian, Bence Hegyi, Mohammad Kazemi-Lari, Anthony Baker, John Shaw, Tamas Banyasz, Ye Chen-Izu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
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Series: | Life |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-1729/11/6/503 |
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