Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images...
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doaj-4a58b230476c444786094a2fcc1d633e2020-11-24T21:48:23ZengElsevierPhotoacoustics2213-59792017-12-018C152710.1016/j.pacs.2017.08.001Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imagingAnant Shah0Nigel Bush1Gary Box2Suzanne Eccles3Jeffrey Bamber4The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics and CRUK Cancer Imaging Centre in the Division of Radiotherapy and Imaging – Sutton, United KingdomThe Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics and CRUK Cancer Imaging Centre in the Division of Radiotherapy and Imaging – Sutton, United KingdomThe Institute of Cancer Research, Division of Cancer Therapeutics – Sutton, United KingdomThe Institute of Cancer Research, Division of Cancer Therapeutics – Sutton, United KingdomThe Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics and CRUK Cancer Imaging Centre in the Division of Radiotherapy and Imaging – Sutton, United KingdomOptoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion. DCE-US was chosen for this particular experiment because US is extremely sensitive to microbubble contrast agents and because microbubbles, like red blood cells but unlike currently available optical contrast agents, do not extravasate. Significant spatial correlations were revealed between the DCE-US properties and tumour blood-oxygen saturation and haemoglobin, as estimated using OAI. It is speculated that DCE-US properties could be applied as surrogate biomarkers for hypoxia when planning clinical radiotherapy or chemotherapy.http://www.sciencedirect.com/science/article/pii/S2213597917300046CEUSMicrobubblesOptoacousticPhotoacousticMSOTRegistration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anant Shah Nigel Bush Gary Box Suzanne Eccles Jeffrey Bamber |
spellingShingle |
Anant Shah Nigel Bush Gary Box Suzanne Eccles Jeffrey Bamber Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging Photoacoustics CEUS Microbubbles Optoacoustic Photoacoustic MSOT Registration |
author_facet |
Anant Shah Nigel Bush Gary Box Suzanne Eccles Jeffrey Bamber |
author_sort |
Anant Shah |
title |
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
title_short |
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
title_full |
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
title_fullStr |
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
title_full_unstemmed |
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
title_sort |
value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging |
publisher |
Elsevier |
series |
Photoacoustics |
issn |
2213-5979 |
publishDate |
2017-12-01 |
description |
Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion. DCE-US was chosen for this particular experiment because US is extremely sensitive to microbubble contrast agents and because microbubbles, like red blood cells but unlike currently available optical contrast agents, do not extravasate. Significant spatial correlations were revealed between the DCE-US properties and tumour blood-oxygen saturation and haemoglobin, as estimated using OAI. It is speculated that DCE-US properties could be applied as surrogate biomarkers for hypoxia when planning clinical radiotherapy or chemotherapy. |
topic |
CEUS Microbubbles Optoacoustic Photoacoustic MSOT Registration |
url |
http://www.sciencedirect.com/science/article/pii/S2213597917300046 |
work_keys_str_mv |
AT anantshah valueofcombiningdynamiccontrastenhancedultrasoundandoptoacoustictomographyforhypoxiaimaging AT nigelbush valueofcombiningdynamiccontrastenhancedultrasoundandoptoacoustictomographyforhypoxiaimaging AT garybox valueofcombiningdynamiccontrastenhancedultrasoundandoptoacoustictomographyforhypoxiaimaging AT suzanneeccles valueofcombiningdynamiccontrastenhancedultrasoundandoptoacoustictomographyforhypoxiaimaging AT jeffreybamber valueofcombiningdynamiccontrastenhancedultrasoundandoptoacoustictomographyforhypoxiaimaging |
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1725892518070976512 |