An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio
Objective: To evaluate the predictive role of the inflammatory parameters, especially monocyte-to-lymphocyte (MLR) ratio, on the diagnosis of prostate cancer (PCa). Meterial and Methods: The data of patients undergoing prostate biopsy between July 2015 and July 2019 were retrospectively analyzed....
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Ali İhsan Taşçı
2021-06-01
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doaj-4a6371ecfade488cade865cc3d8060ad2021-07-07T11:38:09ZengAli İhsan TaşçıYeni Üroloji Dergisi1305-24892687-19552021-06-0116210110910.33719/yud.2021;16-2-794684An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratioMehmet Kutlu Demirkol0https://orcid.org/0000-0003-1678-9889Osman Barut1https://orcid.org/0000-0002-8296-9717Enes Baki Bilecan2https://orcid.org/0000-0003-1094-397XTayfun Sahinkanat3https://orcid.org/0000-0001-8128-0275Omer Faruk Boran4https://orcid.org/0000-0002-0262-9385Mustafa Metin5https://orcid.org/0000-0003-4455-5318Sefa Resim6https://orcid.org/0000-0003-1652-4792Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Kahramanmaras, TurkeyKahramanmaras State Hospital, Department of Urology, Kahramanmaras, TurkeyKahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Urology, Kahramanmaras, TurkeyObjective: To evaluate the predictive role of the inflammatory parameters, especially monocyte-to-lymphocyte (MLR) ratio, on the diagnosis of prostate cancer (PCa). Meterial and Methods: The data of patients undergoing prostate biopsy between July 2015 and July 2019 were retrospectively analyzed. The data including age, PSA, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), MLR and histopathologies were recorded. Patients were grouped as benign prostatic hyperplasia (BPH), PCa and prostatitis according to PBx histopathology and all variables were analyzed. Results: Pathology results of 338 patients are as follows: 124 (36.7%) BPH, 132 (39.1%) PCa and 82 (24.3%) prostatitis. Patients with PCa were older and had higher serum PSA, PLR, NLR and MLR values compared to non-PCa patients. In the comparison made by excluding metastatic patients, only serum PSA and MLR values remained statistically high. All three parameters had significant AUC to predict PCa in entire-cohort, but only the MLR had significant AUC to predict PCa in the cohort which metastatic patients were excluded. Multivariate logistic regression analysis revealed that only serum PSA and MLR values were significant independent predictors of PCa. Conclusion: All inflammatory markers were high in PCa patients, but, only MLR value remained high after metastatic PCa patients were excluded. MLR combination with PSA and age in the multivariate model is significant independent predictor of PCa.https://dergipark.org.tr/tr/download/article-file/1289516i̇nflammatory markersmonocyte-to-lymphocyte ratioprostate biopsyprostate cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehmet Kutlu Demirkol Osman Barut Enes Baki Bilecan Tayfun Sahinkanat Omer Faruk Boran Mustafa Metin Sefa Resim |
spellingShingle |
Mehmet Kutlu Demirkol Osman Barut Enes Baki Bilecan Tayfun Sahinkanat Omer Faruk Boran Mustafa Metin Sefa Resim An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio Yeni Üroloji Dergisi i̇nflammatory markers monocyte-to-lymphocyte ratio prostate biopsy prostate cancer |
author_facet |
Mehmet Kutlu Demirkol Osman Barut Enes Baki Bilecan Tayfun Sahinkanat Omer Faruk Boran Mustafa Metin Sefa Resim |
author_sort |
Mehmet Kutlu Demirkol |
title |
An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
title_short |
An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
title_full |
An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
title_fullStr |
An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
title_full_unstemmed |
An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
title_sort |
inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio |
publisher |
Ali İhsan Taşçı |
series |
Yeni Üroloji Dergisi |
issn |
1305-2489 2687-1955 |
publishDate |
2021-06-01 |
description |
Objective: To evaluate the predictive role of the inflammatory parameters, especially monocyte-to-lymphocyte (MLR) ratio, on the diagnosis of prostate cancer (PCa).
Meterial and Methods: The data of patients undergoing prostate biopsy between July 2015 and July 2019 were retrospectively analyzed. The data including age, PSA, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), MLR and histopathologies were recorded. Patients were grouped as benign prostatic hyperplasia (BPH), PCa and prostatitis according to PBx histopathology and all variables were analyzed.
Results: Pathology results of 338 patients are as follows: 124 (36.7%) BPH, 132 (39.1%) PCa and 82 (24.3%) prostatitis. Patients with PCa were older and had higher serum PSA, PLR, NLR and MLR values compared to non-PCa patients. In the comparison made by excluding metastatic patients, only serum PSA and MLR values remained statistically high. All three parameters had significant AUC to predict PCa in entire-cohort, but only the MLR had significant AUC to predict PCa in the cohort which metastatic patients were excluded. Multivariate logistic regression analysis revealed that only serum PSA and MLR values were significant independent predictors of PCa.
Conclusion: All inflammatory markers were high in PCa patients, but, only MLR value remained high after metastatic PCa patients were excluded. MLR combination with PSA and age in the multivariate model is significant independent predictor of PCa. |
topic |
i̇nflammatory markers monocyte-to-lymphocyte ratio prostate biopsy prostate cancer |
url |
https://dergipark.org.tr/tr/download/article-file/1289516 |
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