The Clinical Pharmacokinetics and Pharmacodynamics of Warfarin When Combined with Compound Danshen: A Case Study for Combined Treatment of Coronary Heart Diseases with Atrial Fibrillation

The Clinical Pharmacokinetics and Pharmacodynamics of Warfarin When Combined with Compound Danshen: A Case Study for Combined Treatment of Coronary Heart Diseases with Atrial Fibrillation

Warfarin is used as anticoagulant and Compound Danshen prescription (CDP) is able to promote blood circulation. The combination might produce a synergic effect for patients of coronary heart diseases (CHDs) with atrial fibrillation (AF). Whether the combination increases the bleeding risk of warfari...

Full description

Bibliographic Details
Main Authors:	Chunxiao Lv, Changxiao Liu, Zhuhua Yao, Xiumei Gao, Lanjun Sun, Jia Liu, Haibo Song, Ziqiang Li, Xi Du, Jinxia Sun, Yanfen Li, Kui Ye, Ruihua Wang, Yuhong Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-11-01
Series:	Frontiers in Pharmacology
Subjects:	warfarin compound Danshen dripping pill pharmacokinetics pharmacodynamics patients coronary heart diseases
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00826/full

Similar Items

Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity
by: Ke Feng, et al.
Published: (2021-06-01)

Identification of Pharmacokinetic Markers for Guanxin Danshen Drop Pills in Rats by Combination of Pharmacokinetics, Systems Pharmacology, and Pharmacodynamic Assays
by: Hong Yao, et al.
Published: (2018-12-01)

Effect of lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill on the endothelial function and serum biochemical indexes in patients with hypertension and carotid atherosclerosis
by: Yan-Feng Li
Published: (2017-04-01)

Effects of FuFangDanShenDiWan on cell adhesion molecules, endothelin and platelet aggregation rate in senile patients with carotid atherosclerosis
by: LUO Hua, et al.
Published: (2019-09-01)

Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia
by: Kim YJ, et al.
Published: (2019-03-01)

The Effects of Aspirin With Combined Compound Danshen Dropping Pills on Hemorheology and Blood Lipids in Middle-Aged and Elderly Patients With CHD: A Systematic Review and Meta-Analysis
by: Zhi Liu, et al.
Published: (2021-06-01)

Effect of compound danshen dropping pill on angina as well as serum c-reactive protein (CRP) and brain natriuretic peptide (BNP)
by: Jing Ye
Published: (2016-06-01)

Bidirectional Influences of Cranberry on the Pharmacokinetics and Pharmacodynamics of Warfarin with Mechanism Elucidation
by: Chung-Ping Yu, et al.
Published: (2021-09-01)

Synergistic Effects of Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Angiogenesis Behavior in EAhy 926 Cells
by: Xian Zhou, et al.
Published: (2017-11-01)

Clinical research of Danshen injection combined with ligustrazine injection TCM therapy in improving severity of severe preeclampsia patients
by: Hong-Juan Meng, et al.
Published: (2016-02-01)

Clinical effect of Danshen injection iontophoresis combined with Lumbrokinase in early retinal vein occlusion patients
by: Xi-Gang Zhang, et al.
Published: (2015-01-01)

Experimental study of Danshen injection on lumbar radiculitis in rats
by: Ke-Song Shi, et al.
Published: (2019-05-01)

Efficacy observation of danshen injection iontophoresis treatment for vitreous hemorrhage
by: Jing Hao, et al.
Published: (2013-11-01)

Pharmacometric Models for Individualisation of Warfarin in Adults and Children
by: Hamberg, Anna-Karin
Published: (2013)

Analysis of the mechanism of Danshen in osteoarthritis based on network harmacology
by: Chang-Shen Yuan, et al.
Published: (2021-08-01)

Review of Danshen: From its metabolism to possible mechanisms of its biological activities
by: B. Mahalakshmi, et al.
Published: (2021-10-01)

Chemical Analysis of the Herbal Medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)
by: Hanqing Pang, et al.
Published: (2016-01-01)

Effect of Compound Danshen Injection Combined with Labetalol on Liver Function and Placental Growth Factor in Patients with Eclampsia
by: Lin Qi, et al.
Published: (2020-03-01)

Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells
by: Cheng-Yu Yang, et al.
Published: (2017-12-01)

Compound Danshen Dripping Pill Inhibits Retina Cell Apoptosis in Diabetic Rats
by: Qian Zhang, et al.
Published: (2018-10-01)

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban – an oral, direct Factor Xa inhibitor
by: Rolf eBurghaus, et al.
Published: (2014-11-01)

A Pair of New Antioxidant Phenolic Acid Stereoisomers Isolated from Danshen Injection (Lyophilized Powder)
by: Jing Liu, et al.
Published: (2014-02-01)

Double Off-line Two-dimensional Liquid Chromatography for Separation and Identification of Compounds in Salvia Miltiorrhiza (Danshen)
by: Ji-xia Wang, et al.
Published: (2015-07-01)

Study on the Quality Evaluation of Compound Danshen Preparations Based on the xCELLigence Real-Time Cell-Based Assay and Pharmacodynamic Authentication
by: Guojun Yan, et al.
Published: (2018-08-01)

Effect of Danshen injection on PILON fracture healing as well as BMP-7, TGF-β1 and bFGF expression
by: Ze-Qin Chen, et al.
Published: (2016-11-01)

Effect of Danshen injection on oxidative stress and inflammatory cytokines in patients with pregnancy-induced hypertension syndrome
by: Jun-Qing Zhang, et al.
Published: (2016-12-01)

Recommendations on the Clinical Use of Compound Danshen Dripping Pills
by: Writing Group of Recommendations of Expert Panel from Chinese Geriatrics Society on the Clinical Use of Compound Danshen Dripping Pills
Published: (2017-01-01)

A study to investigate the mechanisms of the drug interactions between danshen and warfarin.
Published: (2004)

The effect of Danshen extract on lipoprotein-associated phospholipase A2 levels in patients with stable angina pectoris: study protocol for a randomized controlled trial - the DOLPHIN study
by: A-Di Chen, et al.
Published: (2017-12-01)

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network
by: Dongxue Wu, et al.
Published: (2020-02-01)

Effect of Danshen injection on the vascular endothelial function and renal function in patients with pregnancy induced hypertension syndrome
by: Jun-Qing Zhang, et al.
Published: (2016-12-01)

Anti-inflammation and anti-oxygen free radical effect of adjuvant Danshen injection treatment on viral myocarditis
by: Wen-Bao Liang, et al.
Published: (2016-08-01)

Clinical Therapeutic Effects of Aspirin in Combination with Fufang Danshen Diwan, a Traditional Chinese Medicine Formula, on Coronary Heart Disease: A Systematic Review and Meta-Analysis
by: Jianchun Huang, et al.
Published: (2016-10-01)

Effect of Qishen Yiqi dripping pills combined with trimetazidine on the treatment of chronic heart failure: A meta-analysis
by: Feng Xie, et al.
Published: (2021-05-01)

A study of the relationships between the pharmacokinetics and the pharmacodynamics of warfarin and vitamin K1Ì²
by: Cholerton, S.
Published: (1986)

Bupropion-warfarin combination: A serious complication
by: Amar D Bavle, et al.
Published: (2013-01-01)

The cardioprotective effect of danshen and gegen decoction on rat hearts and cardiomyocytes with post-ischemia reperfusion injury
by: Hu Fan, et al.
Published: (2012-12-01)

Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells
by: Xian Zhou, et al.
Published: (2019-02-01)

Mekanik Kalp Kapaklı Hastalarda Antikoagülan Kullanımı ve Warfarin Direnci
by: Ergun Salman, et al.
Published: (2015-02-01)

Clinical observation of Zhengyuanyunsheng dripping pills for the treatment of non-proliferative diabetic macular edema
by: Xiao-Kang Guan, et al.
Published: (2013-10-01)