Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases
Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction...
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doaj-4a6e09b2c0a440058177d7ca746793bb2020-11-25T02:50:30ZengMDPI AGBiomolecules2218-273X2020-09-01101359135910.3390/biom10101359Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic DiseasesJessica Tozour0Francine Hughes1Arnaud Carrier2Didier Vieau3Fabien Delahaye4Department of obstetrics and gynecology, NYU Winthrop Hospital, Mineola, NY 11501, USAObstetrics & Gynecology and Women’s Health, Division of Maternal-Fetal Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USAUniv. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur Lille, U1283-UMR 8199—EGID, F-59000 Lille, FranceUniv. Lille, Inserm, CHU Lille, U1172—LilNCog (JPARC)Lille Neurosciences & Cognition, F-59000 Lille, FranceUniv. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur Lille, U1283-UMR 8199—EGID, F-59000 Lille, FranceWorldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction passed from one generation to another. Metabolic diseases are complex and caused by the interplay between genetic and environmental factors. High-glucose exposure during in utero development, as observed with gestational diabetes mellitus (GDM), is an established risk factor for metabolic diseases. Despite intense efforts to better understand this phenomenon of early memory little is known about the molecular mechanisms associating early exposure to long-term diseases risk. However, evidence promotes glucose associated oxidative stress as one of the molecular mechanisms able to influence susceptibility to metabolic diseases. Thus, we decided here to further explore the relationship between early glucose exposure and cellular stress in the context of early development, and focus on the concept of glycemic memory, its consequences, and sexual dimorphic and epigenetic aspects.https://www.mdpi.com/2218-273X/10/10/1359programmingmetabolic diseaseprenatal hyperglycemiaoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jessica Tozour Francine Hughes Arnaud Carrier Didier Vieau Fabien Delahaye |
spellingShingle |
Jessica Tozour Francine Hughes Arnaud Carrier Didier Vieau Fabien Delahaye Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases Biomolecules programming metabolic disease prenatal hyperglycemia oxidative stress |
author_facet |
Jessica Tozour Francine Hughes Arnaud Carrier Didier Vieau Fabien Delahaye |
author_sort |
Jessica Tozour |
title |
Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases |
title_short |
Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases |
title_full |
Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases |
title_fullStr |
Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases |
title_full_unstemmed |
Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases |
title_sort |
prenatal hyperglycemia exposure and cellular stress, a sugar-coated view of early programming of metabolic diseases |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2020-09-01 |
description |
Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction passed from one generation to another. Metabolic diseases are complex and caused by the interplay between genetic and environmental factors. High-glucose exposure during in utero development, as observed with gestational diabetes mellitus (GDM), is an established risk factor for metabolic diseases. Despite intense efforts to better understand this phenomenon of early memory little is known about the molecular mechanisms associating early exposure to long-term diseases risk. However, evidence promotes glucose associated oxidative stress as one of the molecular mechanisms able to influence susceptibility to metabolic diseases. Thus, we decided here to further explore the relationship between early glucose exposure and cellular stress in the context of early development, and focus on the concept of glycemic memory, its consequences, and sexual dimorphic and epigenetic aspects. |
topic |
programming metabolic disease prenatal hyperglycemia oxidative stress |
url |
https://www.mdpi.com/2218-273X/10/10/1359 |
work_keys_str_mv |
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