Integrin Activation: Implications for Axon Regeneration

Integrin Activation: Implications for Axon Regeneration

Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out...

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Bibliographic Details
Main Authors: Menghon Cheah, Melissa R. Andrews
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Cells
Subjects:
extracellular matrix
gene therapy
integrin activation
kindlin
regeneration
talin
tenascin
Online Access:http://www.mdpi.com/2073-4409/7/3/20
Description
Summary:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.
ISSN:2073-4409

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