Integrin Activation: Implications for Axon Regeneration

Integrin Activation: Implications for Axon Regeneration

Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out...

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Bibliographic Details
Main Authors: Menghon Cheah, Melissa R. Andrews
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Cells
Subjects:
extracellular matrix
gene therapy
integrin activation
kindlin
regeneration
talin
tenascin
Online Access:http://www.mdpi.com/2073-4409/7/3/20
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spelling doaj-4a7ce183384345df9d99d12194fc26702020-11-24T22:32:39ZengMDPI AGCells2073-44092018-03-01732010.3390/cells7030020cells7030020Integrin Activation: Implications for Axon RegenerationMenghon Cheah0Melissa R. Andrews1John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UKDepartment of Biological Sciences, University of Southampton, Life Sciences Bldg 85, Highfield Campus, Southampton SO17 1BJ, UKIntegrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.http://www.mdpi.com/2073-4409/7/3/20extracellular matrixgene therapyintegrin activationkindlinregenerationtalintenascin
collection DOAJ
language English
format Article
sources DOAJ
author Menghon Cheah
Melissa R. Andrews
spellingShingle Menghon Cheah
Melissa R. Andrews
Integrin Activation: Implications for Axon Regeneration
Cells
extracellular matrix
gene therapy
integrin activation
kindlin
regeneration
talin
tenascin
author_facet Menghon Cheah
Melissa R. Andrews
author_sort Menghon Cheah
title Integrin Activation: Implications for Axon Regeneration
title_short Integrin Activation: Implications for Axon Regeneration
title_full Integrin Activation: Implications for Axon Regeneration
title_fullStr Integrin Activation: Implications for Axon Regeneration
title_full_unstemmed Integrin Activation: Implications for Axon Regeneration
title_sort integrin activation: implications for axon regeneration
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2018-03-01
description Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.
topic extracellular matrix
gene therapy
integrin activation
kindlin
regeneration
talin
tenascin
url http://www.mdpi.com/2073-4409/7/3/20
work_keys_str_mv AT menghoncheah integrinactivationimplicationsforaxonregeneration
AT melissarandrews integrinactivationimplicationsforaxonregeneration
_version_ 1725733007662252032

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