Integrin Activation: Implications for Axon Regeneration
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out...
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2018-03-01
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Online Access: | http://www.mdpi.com/2073-4409/7/3/20 |
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doaj-4a7ce183384345df9d99d12194fc26702020-11-24T22:32:39ZengMDPI AGCells2073-44092018-03-01732010.3390/cells7030020cells7030020Integrin Activation: Implications for Axon RegenerationMenghon Cheah0Melissa R. Andrews1John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UKDepartment of Biological Sciences, University of Southampton, Life Sciences Bldg 85, Highfield Campus, Southampton SO17 1BJ, UKIntegrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.http://www.mdpi.com/2073-4409/7/3/20extracellular matrixgene therapyintegrin activationkindlinregenerationtalintenascin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Menghon Cheah Melissa R. Andrews |
spellingShingle |
Menghon Cheah Melissa R. Andrews Integrin Activation: Implications for Axon Regeneration Cells extracellular matrix gene therapy integrin activation kindlin regeneration talin tenascin |
author_facet |
Menghon Cheah Melissa R. Andrews |
author_sort |
Menghon Cheah |
title |
Integrin Activation: Implications for Axon Regeneration |
title_short |
Integrin Activation: Implications for Axon Regeneration |
title_full |
Integrin Activation: Implications for Axon Regeneration |
title_fullStr |
Integrin Activation: Implications for Axon Regeneration |
title_full_unstemmed |
Integrin Activation: Implications for Axon Regeneration |
title_sort |
integrin activation: implications for axon regeneration |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2018-03-01 |
description |
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration. |
topic |
extracellular matrix gene therapy integrin activation kindlin regeneration talin tenascin |
url |
http://www.mdpi.com/2073-4409/7/3/20 |
work_keys_str_mv |
AT menghoncheah integrinactivationimplicationsforaxonregeneration AT melissarandrews integrinactivationimplicationsforaxonregeneration |
_version_ |
1725733007662252032 |