Bright/Arid3A Acts as a Barrier to Somatic Cell Reprogramming through Direct Regulation of Oct4, Sox2, and Nanog

Bright/Arid3A Acts as a Barrier to Somatic Cell Reprogramming through Direct Regulation of Oct4, Sox2, and Nanog

We show here that singular loss of the Bright/Arid3A transcription factor leads to reprograming of mouse embryonic fibroblasts (MEFs) and enhancement of standard four-factor (4F) reprogramming. Bright-deficient MEFs bypass senescence and, under standard embryonic stem cell (ESC) culture conditions,...

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Bibliographic Details
Main Authors: Melissa Popowski, Troy D. Templeton, Bum-Kyu Lee, Catherine Rhee, He Li, Cathrine Miner, Joseph D. Dekker, Shari Orlanski, Yehudit Bergman, Vishwanath R. Iyer, Carol F. Webb, Haley Tucker
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671113001525

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