Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization

Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization

Null mutations in the gene encoding the major myelin protein of the central nervous system, proteolipid protein 1 (PLP1), cause an X-linked form of spastic paraplegia (SPG2) associated with axonal degeneration. While motor symptoms are the best known manifestations of this condition, its somatosenso...

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Bibliographic Details
Main Authors: Bérengère Petit, Fabrice Giraudet, Céline Béchon, Laurent Bardin, Paul Avan, Odile Boespflug-Tanguy, Mélina Bégou
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Dysmyelinating disease
Pain
Central sensitization
Transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000126

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