A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration
A lot of research studies have shown that many complex human diseases are associated not only with microRNAs (miRNAs) but also with long noncoding RNAs (lncRNAs). However, most of the current existing studies focus on the prediction of disease-related miRNAs or lncRNAs, and to our knowledge, until n...
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doaj-4a9047195923412da20ede5e0a9d522e2020-11-25T01:18:01ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182019-01-01201910.1155/2019/76148507614850A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal IterationZhanwei Xuan0Xiang Feng1Jingwen Yu2Pengyao Ping3Haochen Zhao4Xianyou Zhu5Lei Wang6College of Computer Engineering & Applied Mathematics, Changsha University, Changsha 410001, Hunan, ChinaCollege of Computer Engineering & Applied Mathematics, Changsha University, Changsha 410001, Hunan, ChinaKey Laboratory of Intelligent Computing & Information Processing, Xiangtan University, 411105 Xiangtan, ChinaKey Laboratory of Intelligent Computing & Information Processing, Xiangtan University, 411105 Xiangtan, ChinaKey Laboratory of Intelligent Computing & Information Processing, Xiangtan University, 411105 Xiangtan, ChinaKey Laboratory of Intelligent Computing & Information Processing, Xiangtan University, 411105 Xiangtan, ChinaCollege of Computer Engineering & Applied Mathematics, Changsha University, Changsha 410001, Hunan, ChinaA lot of research studies have shown that many complex human diseases are associated not only with microRNAs (miRNAs) but also with long noncoding RNAs (lncRNAs). However, most of the current existing studies focus on the prediction of disease-related miRNAs or lncRNAs, and to our knowledge, until now, there are few literature studies reported to pay attention to the study of impact of miRNA-lncRNA pairs on diseases, although more and more studies have shown that both lncRNAs and miRNAs play important roles in cell proliferation and differentiation during the recent years. The identification of disease-related genes provides great insight into the underlying pathogenesis of diseases at a system level. In this study, a novel model called PADLMHOOI was proposed to predict potential associations between diseases and lncRNA-miRNA pairs based on the higher-order orthogonal iteration, and in order to evaluate its prediction performance, the global and local LOOCV were implemented, respectively, and simulation results demonstrated that PADLMHOOI could achieve reliable AUCs of 0.9545 and 0.8874 in global and local LOOCV separately. Moreover, case studies further demonstrated the effectiveness of PADLMHOOI to infer unknown disease-related lncRNA-miRNA pairs.http://dx.doi.org/10.1155/2019/7614850 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhanwei Xuan Xiang Feng Jingwen Yu Pengyao Ping Haochen Zhao Xianyou Zhu Lei Wang |
spellingShingle |
Zhanwei Xuan Xiang Feng Jingwen Yu Pengyao Ping Haochen Zhao Xianyou Zhu Lei Wang A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration Computational and Mathematical Methods in Medicine |
author_facet |
Zhanwei Xuan Xiang Feng Jingwen Yu Pengyao Ping Haochen Zhao Xianyou Zhu Lei Wang |
author_sort |
Zhanwei Xuan |
title |
A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration |
title_short |
A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration |
title_full |
A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration |
title_fullStr |
A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration |
title_full_unstemmed |
A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration |
title_sort |
novel method for predicting disease-associated lncrna-mirna pairs based on the higher-order orthogonal iteration |
publisher |
Hindawi Limited |
series |
Computational and Mathematical Methods in Medicine |
issn |
1748-670X 1748-6718 |
publishDate |
2019-01-01 |
description |
A lot of research studies have shown that many complex human diseases are associated not only with microRNAs (miRNAs) but also with long noncoding RNAs (lncRNAs). However, most of the current existing studies focus on the prediction of disease-related miRNAs or lncRNAs, and to our knowledge, until now, there are few literature studies reported to pay attention to the study of impact of miRNA-lncRNA pairs on diseases, although more and more studies have shown that both lncRNAs and miRNAs play important roles in cell proliferation and differentiation during the recent years. The identification of disease-related genes provides great insight into the underlying pathogenesis of diseases at a system level. In this study, a novel model called PADLMHOOI was proposed to predict potential associations between diseases and lncRNA-miRNA pairs based on the higher-order orthogonal iteration, and in order to evaluate its prediction performance, the global and local LOOCV were implemented, respectively, and simulation results demonstrated that PADLMHOOI could achieve reliable AUCs of 0.9545 and 0.8874 in global and local LOOCV separately. Moreover, case studies further demonstrated the effectiveness of PADLMHOOI to infer unknown disease-related lncRNA-miRNA pairs. |
url |
http://dx.doi.org/10.1155/2019/7614850 |
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