Gene expression profiling in multiple sclerosis brain

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and the leading cause of non-traumatic neurological disability in young adults in the United States and Europe. The clinical disease course is variable and starts with reversible episodes of neurolo...

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Main Authors:	Ranjan Dutta, Bruce D. Trapp
Format:	Article
Language:	English
Published:	Elsevier 2012-01-01
Series:	Neurobiology of Disease
Subjects:	Multiple sclerosis Microarray Myelin
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996110003967

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spelling	doaj-4a92090881644a04a4ffea09fc2cca9c2021-03-22T12:36:17ZengElsevierNeurobiology of Disease1095-953X2012-01-01451108114Gene expression profiling in multiple sclerosis brainRanjan Dutta0Bruce D. Trapp1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USACorresponding author. Department of Neurosciences/NC30, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. Fax: +1 216 444 7927.; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USAMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and the leading cause of non-traumatic neurological disability in young adults in the United States and Europe. The clinical disease course is variable and starts with reversible episodes of neurological disability in the third or fourth decade of life. Microarray-based comparative gene profiling provides a snapshot of genes underlying a particular condition. Several large scale microarray studies have been conducted using brain tissue from MS patients. In this review, we summarize existing data from different gene expression profiling studies and how they relate to understand the pathogenesis of MS.http://www.sciencedirect.com/science/article/pii/S0969996110003967Multiple sclerosisMicroarrayMyelin
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ranjan Dutta Bruce D. Trapp
spellingShingle	Ranjan Dutta Bruce D. Trapp Gene expression profiling in multiple sclerosis brain Neurobiology of Disease Multiple sclerosis Microarray Myelin
author_facet	Ranjan Dutta Bruce D. Trapp
author_sort	Ranjan Dutta
title	Gene expression profiling in multiple sclerosis brain
title_short	Gene expression profiling in multiple sclerosis brain
title_full	Gene expression profiling in multiple sclerosis brain
title_fullStr	Gene expression profiling in multiple sclerosis brain
title_full_unstemmed	Gene expression profiling in multiple sclerosis brain
title_sort	gene expression profiling in multiple sclerosis brain
publisher	Elsevier
series	Neurobiology of Disease
issn	1095-953X
publishDate	2012-01-01
description	Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and the leading cause of non-traumatic neurological disability in young adults in the United States and Europe. The clinical disease course is variable and starts with reversible episodes of neurological disability in the third or fourth decade of life. Microarray-based comparative gene profiling provides a snapshot of genes underlying a particular condition. Several large scale microarray studies have been conducted using brain tissue from MS patients. In this review, we summarize existing data from different gene expression profiling studies and how they relate to understand the pathogenesis of MS.
topic	Multiple sclerosis Microarray Myelin
url	http://www.sciencedirect.com/science/article/pii/S0969996110003967
work_keys_str_mv	AT ranjandutta geneexpressionprofilinginmultiplesclerosisbrain AT brucedtrapp geneexpressionprofilinginmultiplesclerosisbrain
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Gene expression profiling in multiple sclerosis brain

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