Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever.
BACKGROUND: Development of antiviral drugs that have broad-spectrum activity against a number of viral infections would be of significant benefit. Due to the evolution of resistance to currently licensed antiviral drugs, development of novel anti-influenza drugs is in progress, including Favipiravir...
Main Authors: | Amy L Caroline, Diana S Powell, Laura M Bethel, Tim D Oury, Douglas S Reed, Amy L Hartman |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-04-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC3983105?pdf=render |
Similar Items
-
Antiviral Activity of Favipiravir (T-705) Against Lethal Rift Valley Fever Virus Infection in Hamsters
by: Scharton, Dionna
Published: (2014) -
Inflammatory biomarkers associated with lethal Rift Valley fever encephalitis in the Lewis rat model
by: Amy L. Caroline, et al.
Published: (2016-01-01) -
Choice of inbred rat strain impacts lethality and disease course after respiratory infection with Rift Valley Fever virus
by: Jacquelyn M. Bales, et al.
Published: (2012-08-01) -
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.
by: Lisa Oestereich, et al.
Published: (2014-05-01) -
Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats.
by: Joseph R Albe, et al.
Published: (2019-06-01)