Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex
Huntington disease (HD) is a neurological disorder caused by polyglutamine expansions in mutated Huntingtin (mHtt) proteins, rendering them prone to form inclusion bodies (IB). We report that in yeast, such IB formation is a factor-dependent process subjected to age-related decline. A genome-wide, h...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/11792 |