Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases
Nephrogenic systemic fibrosis (NSF) has now been virtually eliminated by the discovery of its association with gadolinium-based contrast agents (GBCAs) and the consequent reduced use of GBCA-enhanced magnetic resonance imaging (MRI) in severe renal failure patients. This review of 408 biopsy-confirm...
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Wolters Kluwer Medknow Publications
2011-01-01
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doaj-4a99c2c29dae4b9a9a7c5557c95211882020-11-25T00:47:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112011-01-01561657310.4103/0019-5154.77556Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed casesZhitong ZouLin MaNephrogenic systemic fibrosis (NSF) has now been virtually eliminated by the discovery of its association with gadolinium-based contrast agents (GBCAs) and the consequent reduced use of GBCA-enhanced magnetic resonance imaging (MRI) in severe renal failure patients. This review of 408 biopsy-confirmed cases shows how to minimize NSF risk when performing GBCA-enhanced MRI or magnetic resonance angiography. The absence of any NSF cases in patients less than 8 years old or greater than 87 years old suggests that infants and elderly patients are already protected. Limiting GBCA dose to a maximum of 0.1 mMol/kg, dialyzing dialysis patients quickly following GBCA administration, delaying administration of GBCA in acute renal failure until after renal function returns or dialysis is initiated, and avoiding nonionic linear GBCA in renal failure patients, especially when there are pro-inflammatory conditions, appear to have reduced NSF risk to the point where safe GBCA-enhanced MRI is possible in most patients.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=65;epage=73;aulast=ZouContrast agentsfibrosisgadoliniumkidney diseasemagnetic resonance angiographymagnetic resonance imagingnephrogenic systemic fibrosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhitong Zou Lin Ma |
spellingShingle |
Zhitong Zou Lin Ma Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases Indian Journal of Dermatology Contrast agents fibrosis gadolinium kidney disease magnetic resonance angiography magnetic resonance imaging nephrogenic systemic fibrosis |
author_facet |
Zhitong Zou Lin Ma |
author_sort |
Zhitong Zou |
title |
Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases |
title_short |
Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases |
title_full |
Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases |
title_fullStr |
Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases |
title_full_unstemmed |
Nephrogenic systemic fibrosis: Review of 408 biopsy-confirmed cases |
title_sort |
nephrogenic systemic fibrosis: review of 408 biopsy-confirmed cases |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dermatology |
issn |
0019-5154 1998-3611 |
publishDate |
2011-01-01 |
description |
Nephrogenic systemic fibrosis (NSF) has now been virtually eliminated by the discovery of its association with gadolinium-based contrast agents (GBCAs) and the consequent reduced use of GBCA-enhanced magnetic resonance imaging (MRI) in severe renal failure patients. This review of 408 biopsy-confirmed cases shows how to minimize NSF risk when performing GBCA-enhanced MRI or magnetic resonance angiography. The absence of any NSF cases in patients less than 8 years old or greater than 87 years old suggests that infants and elderly patients are already protected. Limiting GBCA dose to a maximum of 0.1 mMol/kg, dialyzing dialysis patients quickly following GBCA administration, delaying administration of GBCA in acute renal failure until after renal function returns or dialysis is initiated, and avoiding nonionic linear GBCA in renal failure patients, especially when there are pro-inflammatory conditions, appear to have reduced NSF risk to the point where safe GBCA-enhanced MRI is possible in most patients. |
topic |
Contrast agents fibrosis gadolinium kidney disease magnetic resonance angiography magnetic resonance imaging nephrogenic systemic fibrosis |
url |
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=1;spage=65;epage=73;aulast=Zou |
work_keys_str_mv |
AT zhitongzou nephrogenicsystemicfibrosisreviewof408biopsyconfirmedcases AT linma nephrogenicsystemicfibrosisreviewof408biopsyconfirmedcases |
_version_ |
1725260703462326272 |