The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.

The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.

Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages, is transcriptionally regulated by the nuclear receptor Liver X Receptor (LXR) and Retinoid X Receptor (RXR) heterodimer. Given that LXR exerts a protective immune response against M. tuberculosis, here we a...

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Bibliographic Details
Main Authors: Lucía Sanjurjo, Núria Amézaga, Cristina Vilaplana, Neus Cáceres, Elena Marzo, Marta Valeri, Pere-Joan Cardona, Maria-Rosa Sarrias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817138?pdf=render

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http://europepmc.org/articles/PMC3817138?pdf=render

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