The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.
Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages, is transcriptionally regulated by the nuclear receptor Liver X Receptor (LXR) and Retinoid X Receptor (RXR) heterodimer. Given that LXR exerts a protective immune response against M. tuberculosis, here we a...
Main Authors: | Lucía Sanjurjo, Núria Amézaga, Cristina Vilaplana, Neus Cáceres, Elena Marzo, Marta Valeri, Pere-Joan Cardona, Maria-Rosa Sarrias |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3817138?pdf=render |
Similar Items
-
CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3
by: Lucía Sanjurjo, et al.
Published: (2018-03-01) -
Prophylactic effect of a therapeutic vaccine against TB based on fragments of Mycobacterium tuberculosis.
by: Cristina Vilaplana, et al.
Published: (2011-01-01) -
Caracterización funcional de la proteína scavenger AIM en la respuesta anti-infecciosa del macrófago
by: Sanjurjo Bouza, Lucía
Published: (2014) -
Low dose aerosol fitness at the innate phase of murine infection better predicts virulence amongst clinical strains of Mycobacterium tuberculosis.
by: Neus Caceres, et al.
Published: (2012-01-01) -
Regulatory T Cells in Mycobacterium tuberculosis Infection
by: Paula Cardona, et al.
Published: (2019-09-01)