Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013). Here we show that mouse embryonic fibroblasts d...

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Bibliographic Details
Main Authors: Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
cell death
necrosis
autophagy
apoptosis
Online Access:https://elifesciences.org/articles/30543

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